kainate receptor


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kai·nate re·cep·tor

a type of glutamate receptor that participates in excitatory neurotransmission.
References in periodicals archive ?
Swanson, "Kainate receptor posttranslational modifications differentially regulate association with 4.1N to control activity-dependent receptor endocytosis," Journal of Biological Chemistry, vol.
The gene expression assay clearly indicated that glutamate receptors (NMDA and kainate receptor) are involved in glutamate excitotoxicity and contribute to oxidative damage of neural cells derived from 46C cells.
Our previous study showed that GluR5-containing kainate receptors (non-NMDA glutamate receptor) regulate the inhibitory synaptic transmission through endogenous glutamate; therefore, we tested how neonatal propofol and etomidate exposure affect endogenous glutamatergic tonic regulation to inhibitory synaptic transmission in P90 approximately rats.[sup][17] To determine whether NMDA receptors are involved in the tonic glutamatergic input on GABAergic neurotransmission, we tested the effect of AP5, a selective NMDA receptor antagonist, on sIPSCs.
Both antidepressant drugs and antibipolar drugs affect GluK2, but the effects are different, and further studies of this kainate receptor are warranted in both major depression and bipolar disease.
Kainate Receptors. The existence of kainate receptors has been known for sometime, yet little is understood about the contribution to the pathology of PD or the potential of kainate receptors as therapeutic targets in PD and PD-LID.
These key SUMO proteins produce subtle responses to the brain's activity levels to regulate the amount of information transmitted by kainate receptors - responsible for communication between nerve cells and whose activation can lead to epileptic seizures and nerve cell death.
It was also noted that (a) presynaptic LTP expression was enhanced at synapses that had low baseline estimates of presynaptic function (Foster and McNaughton, 1991; Larkman et al., 1992) and (b) pharmacological treatments that affected presynaptic kainate receptors (Lauri et al., 2007) or presynaptic kinase signaling (AC and PKA) produced a more pronounced long-lasting increase in synaptic efficacy in hippocampal slices from juvenile rats compared to adults (Chavez-Noriega and Stevens, 1992, 1994; Dumas, 2005a).
(81) KYNA is a tryptophan metabolite that has selective activity against NMDA, quisqualate, and kainate receptors in the central nervous system.
It disrupts normal neurochemical transmission in the brain by binding to certain glutamate receptors, the so-called kainate receptors, of neuronal cells.
For example, 14-3-3 interacts with GluK2a, a subunit of the kainate receptor (KAR) that mediates postsynaptic transmission, synaptic plasticity, and neuronal excitability [51].
Kainic acid (KA) is a potent neuroexcitatory amino acid to activate kainate receptor in the brain and is typically used for developing an animal epilepsy model [5-7].
Mayer, "Crystal structures of the GluR5 and GluR6 ligand binding cores: molecular mechanisms underlying kainate receptor selectivity," Neuron, vol.