KCNQ2

(redirected from KV7.2)

KCNQ2

A gene on chromosome 20q13.3 that encodes a protein which, with the KCNQ3 protein product, forms the M channel, a slowly activating and deactivating potassium channel central to regulating neuronal excitability.

Molecular pathology
KCNQ3 mutations are associated with benign familial neonatal seizures type 1 (e.g., benign familial neonatal convulsions).
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References in periodicals archive ?
There are five different Kv7 [K.sup.+] channel subtypes (Kv7.1-Kv7.5), and four (Kv7.2-Kv7.5) of these are located in the nervous system; Kv7.2 and Kv7.3 are associated with the slow voltage-gated M-channel (8, 9).
Kv7.2, 7.3, and 7.5 channels and functional Kv7-M currents are found in the sensory nerves' peripheral terminals, cell bodies, axons, and central terminals.
XEN1101 is a Kv7 potassium channel opener being developed by Xenon for the treatment of epilepsy including: treatment-resistant adult and pediatric focal seizures as well as rare, pediatric forms of epilepsy, such as EIEE7, an early infantile epileptic encephalopathy associated with mutations in the KCNQ2 gene encoding the Kv7.2 potassium channel; and potentially other neurological disorders.