EPCAM

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EPCAM

A gene on chromosome 2p21 that encodes a carcinoma-associated antigen expressed on most normal epithelial cells and gastrointestinal carcinomas, which functions as a homotypic calcium-independent cell adhesion molecule. EPCAM is thought to function as a relay molecule between intestinal epithelial cells and intraepithelial lymphocytes at the mucosa, providing an immune barrier to infection. It is of interest in oncology as a target for cancer immunotherapy. It upregulates expression of FABP5, MYC and cyclins A and E.

Molecular pathology
Defects in EPCAM cause congenital tufting enteropathy (diarrhoea type 5).
References in periodicals archive ?
We are optimistic because at the end of the day we put a proposition together which is good for Zain Kuwait who are selling, and which is, we believe, good for the Zain KSA shareholders," Kaliaropoulos said.
3 million active customers, today confirmed that it has increased its shareholding in Zain KSA to 37.
Prior to the acquisition, KSA and Alliance enjoyed a good working relationship and have cooperated in the design of several street, environmental, and airport projects over the past 20 years.
While Middle Eastern consumers are renowned for their brand loyalty, over half of consumers in both the KSA and UAE have given up some of their favourite grocery brands because of economic conditions.
In Q1, Zain KSA reduced operational losses by 46% to SR233 million ($62 million), compared to SR435 million in the same period last year.
Over 20 insurers participated at the workshop from the KSA insurance market.
The agreement was signed during a press conference attended by Fadi Kawar, CEO of Lebara Mobile KSA, and Ramadan Ding, CEO of Huawei Saudi Arabia, alongside the executive teams from both companies.
5%, the "Restaurants and hotels" group in the KSA by 2.
Conrad Yang, country manager, KSA TP-LINK Middle East,
Zain KSA today announces that, for the first time in its history, it has achieved operational break-even during a quarter.
Additionally, the KSA has an economy that is heavily skewed towards petroleum, with 90 per cent of all revenues coming from oil.