KRT7


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KRT7

A gene on chromosome 12q13.13 that encodes a type-II cytokeratin specifically expressed in the simple epithelia of internal organs, glands, ducts and blood vessels.
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Se identificaron un total de 48 PNSs de los cuales 14 PNSs se encuentran distribuidos en 8 genes de queratina de epitelio de tipo I (KRT9, KRT12, KRT13, KRT14, KRT16, KRT18, KRT20, KRT25); 23 PNSs distribuidos en los 8 genes de queratina de epitelio de tipo II (KRT1, KRT3, KRT5, KRT6a, KRT7, KRT8, KRT71, KRT80); 4 PNSs en los genes de queratina de fibra de tipo I (KRT31, KRT32, KIRT40) y 7 PNSs en los genes de queratina de fibra de tipo II (KRT81, KRT82, KRT83).
Los genes KRT80, KRT7, KRT81, KRT83, KRT82, KRT6a, KRT6b, KRT6c, KRT5, KRT71, KRT2, KRT1, KRT3, KRT4, KRT79, KRT8 y KRT18 estan ubicados en el cromosoma 12 q13, 3 q23, 5 q21 de humano, ovino y cabra respectivamente y el scaffold 36 en alpaca.
Asi mismo, en el scaffold 36, los posibles PNSs de los genes KRT80, KRT7, KRT81, KRT83, KRT82 KRT6a, KRT5, KRT71, KRT1, KRT3, KRT8y KRT18, formaron dos haplotipos, 5'CACTAAAGAGCC3' y 5TGTTAGGAGATA3'.
Figure 3: QPCR analysis of genes related to differentiation for all cell lines on LN521: mesodermal markers KDR and ACTC1; ectodermal markers PAX6 and NEUROD1; endodermal markers GATA6, AFP and DDX4; trophoblast marker KRT7. Gene expression relative to that of GAPDH is shown before (grey bars) and after spontaneous differentiation (red bars).
The gene list for gene fusions and expression consists of RET, PPARG, NTRK1, NTRK3, ALK, IGF2BP3, BRAF, MET, CALCA, PTH, SLC5A5, TG, TTF1, KRT7 and KRT20.
The KRT7 and KRT20 genes both belong to the keratin gene family, which consists of 54 functional genes.
KRT7 and KRT20 along with the other members of the keratin gene family have been utilized as diagnostic markers to determine the origin tissue, due to the characteristic cell-type, differentiation and functional status-dependent expression pattern of cytokeratin in epithelial cells.
Almost all thyroidal tumor's expression levels for KRT7 and KRT20 have been found to be positive and negative, respectively.