KRT4

KRT4

A gene on chromosome 12q13.13 that encodes a type-II cytokeratin that is specifically co-expressed in differentiated layers of mucosal and oesophageal epithelia with family member KRT13.

Molecular pathology
KRT4 mutations are associated with white sponge nevus, which is characterised by oral, oesophageal and anal leukoplakia.
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A significant decline was seen with KRT1, KRT4, KRT13, and KRT77 while others were strongly upregulated (e.
Therefore the observed decrease in keratin expression (KTR24 in the discriminative genes, KA36, KRT4, KRT9, in the top 100 associated transcripts) may be attributable to the presence of fewer keratin-producing cells in direct contact with the amniotic fluid in NTD cases.
5] Human genes: SLA, Src-like-adaptor; LST1, leukocyte-specific transcript 1; BENE, BENE protein; KRT24, keratin 24; C9orf3, chromosome 9 open reading frame 3; KIAA0779, KIAA0779 protein; TMCC1, transmembrane and coiledcoil domain family 1; ZNF292, zinc finger protein 292; LOC153222, adult retina protein; CBEP4, cytoplasmic polyadenylation element binding protein4; TICD2, tigger transposable element derived 2; UBAP2, ubiquitin associated protein 2; AVPI1, arginine vasopressin-induced 1; KIAA0669, the same as TSC22D2; TSC22D2, TSC22 domain family, member 2; DHFR, dihydrofolate reductase; MTR, 5-methoyltetrahydrofolate-homocysteine methyltransferase; ATIC, 5-aminoimidazole-4-carboxamide ribonucleotide; KA36, type I hair keratin; KRT4, Keratin 4; KRT9, Keratin 9.