KRT20

KRT20

A gene on chromosome 17q21.2 that encodes a type-I keratin, an intermediate filament protein that is a major cellular protein of mature enterocytes and goblet cells, and is specifically expressed in gastric and intestinal mucosa.
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Se estudiaron 31 genes de queratina reportados para ovinos, cabras y humanos entre los cuales tenemos 12 genes del epitelio de tipo I (KRT9, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT20 y KRT25), 13 genes del epitelio de tipo II (KRT1, KRT2, KRT3, KRT4, KRT5, KRT6a, KRT6b, KRT6c, KRT7, KRT8, KRT71, KRT79 y KRT80), 3 genes de la fibra de tipo I (KRT31, KRT32 y KRT40) y 3 genes de la fibra de tipo II (KRT81, KRT82 y KRT83) (Zhidong et al.
Uno de estos tipos de estudio, es el estudio por inmunohistoquimica, que, en el caso del adenocarcinoma del colon, utiliza con mas frecuencia los marcadores tumorales Citoqueratina 20 (KRT20), Citoqueratina 7 (KRT7) y el CDX2.
Tested genes include AKT1, ALK, AXL, BRAF, CALCA, CCND1, CTNNB1, DDR2, EGFR, ERBB2, FGFR1, FGFR2, FGFR3, GNAS, HRAS, IDH1, IDH2, KRAS, KRT20, KRT7, MAP2K1, MET, NRAS, NRG1, NTRK1, NTRK2, NTRK3, PIK3CA, PPARG, PTH, RAF1, RET, ROS1, SLC5A5, THADA, TTF1, CHMP2A, GPI, RAB7A, and VCP.
ADAMTS9 CRIP2 ENGASE IL23A RT1-DA AHCY CTGF ERO1LB KRT20 S100A4 AMIGO3 DDIT3 ETV5 MANF SDF2L1 ANKRD37 DERL3 FGF18 MFSD2 SEC23B ATMIN DNAJB11 FOLR1 NR4A2 SEL1L BCAM DNAJB9 GGCT NUPR1 SLIT1 BET1 DNAJC3 GMPPB PDIA4 TM4SF1 CASP4 DUOX2 HSP90B1 PRIMA1 TMEM140 CDH1 DUSP5 HSPA5 PRSS8 TMEM66 COQ10B DYNLRB2 HYOU1 RIL ZFAND2A CRELD2 ELOVL2 IGF2BP2 RIOK3 Table 3: Target genes of the transcription factor PAX8 (gene symbol) [37].
ThyroSeq v2 panel Gene mutations Gene fusions Gene expression (RNA) (DNA) (RNA) BRAF RET RET PGK1 Pan-cell NRAS TSHR PPARG KRT7 HRAS AKT1 NTRK1 TG Thyroid cell KRAS TP53 NTRK3 TTF1 PIK3CA GNAS BRAF NIS PTEN CTNNB1 ALK Calcitonin MTC TERT EIF1AX PTH Parathyroid KRT20 Metastatic
KRT13 was reported to occur in combination with KRT8, KRT18 and KRT20 in UCB [11].
NEFM (neurofilament, medium polypeptide), PLA2G10 (phospholipase A2, group X), and KRT20 (keratin 20) are upregulated more than 3-fold in tumors with poor prognosis.
[2] Human genes: KRT20, keratin 20; CA1, carbonic anhydrase I; MS4A12, membrane-spanning 4-domains, subfamily A, member 12; CD177, CD177 molecule; SLC26AA3, solute carrier family 26, member 3.
The gene list for gene fusions and expression consists of RET, PPARG, NTRK1, NTRK3, ALK, IGF2BP3, BRAF, MET, CALCA, PTH, SLC5A5, TG, TTF1, KRT7 and KRT20.
(51) Because serrated polyps, including hyperplastic polyps, sessile serrated adenomas, and traditional serrated adenomas, are associated with aberrant gastric-type differentiation, the CIMP-H/MSI-H subtype is characterized by a gain of gastric differentiation (ANXA10, TFF2, and MUC5AC expression) and loss of intestinal expression (CDX2 and KRT20 loss).