KRT20

KRT20

A gene on chromosome 17q21.2 that encodes a type-I keratin, an intermediate filament protein that is a major cellular protein of mature enterocytes and goblet cells, and is specifically expressed in gastric and intestinal mucosa.
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51) Because serrated polyps, including hyperplastic polyps, sessile serrated adenomas, and traditional serrated adenomas, are associated with aberrant gastric-type differentiation, the CIMP-H/MSI-H subtype is characterized by a gain of gastric differentiation (ANXA10, TFF2, and MUC5AC expression) and loss of intestinal expression (CDX2 and KRT20 loss).
2] Human genes: KRT20, keratin 20; CA1, carbonic anhydrase I; MS4A12, membrane-spanning 4-domains, subfamily A, member 12; CD177, CD177 molecule; SLC26AA3, solute carrier family 26, member 3.