KRT2

KRT2

A gene on chromosome 12q13.13 that encodes a type-II cytokeratin primarily expressed in the upper spinous layer of the epidermis. 

Molecular pathology
KRT2 mutations are associated with bullous congenital ichthyosiform erythroderma.
References in periodicals archive ?
Se estudiaron 31 genes de queratina reportados para ovinos, cabras y humanos entre los cuales tenemos 12 genes del epitelio de tipo I (KRT9, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT20 y KRT25), 13 genes del epitelio de tipo II (KRT1, KRT2, KRT3, KRT4, KRT5, KRT6a, KRT6b, KRT6c, KRT7, KRT8, KRT71, KRT79 y KRT80), 3 genes de la fibra de tipo I (KRT31, KRT32 y KRT40) y 3 genes de la fibra de tipo II (KRT81, KRT82 y KRT83) (Zhidong et al.
Los genes KRT80, KRT7, KRT81, KRT83, KRT82, KRT6a, KRT6b, KRT6c, KRT5, KRT71, KRT2, KRT1, KRT3, KRT4, KRT79, KRT8 y KRT18 estan ubicados en el cromosoma 12 q13, 3 q23, 5 q21 de humano, ovino y cabra respectivamente y el scaffold 36 en alpaca.
The composition excludes materials that complex with the artichoke leaf extract and the carob fruit extract, and wherein the artichoke leaf extract and the carob fruit extract are present at an amount to provide a synergistic increase in the up-regulation of at least one epidermal-associated gene selected from the group consisting of KRT2, KRT6A, CLDN1, LOR, FLG, IVL, KRT10, AQP3, and KRT14 according to an ex vivo tissue analysis.