KRT16

KRT16

A gene on chromosome 17q21.2 that encodes a type-I keratin, an intermediate filament protein that provides the structural integrity of epithelial cells. KRT16 may be co-expressed with KRT14 in the oesophagus, tongue and hair follicles.

Molecular pathology
KRT16 mutations are associated with pachyonychia congenita type 1, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus.
Mentioned in ?
References in periodicals archive ?
Se estudiaron 31 genes de queratina reportados para ovinos, cabras y humanos entre los cuales tenemos 12 genes del epitelio de tipo I (KRT9, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT20 y KRT25), 13 genes del epitelio de tipo II (KRT1, KRT2, KRT3, KRT4, KRT5, KRT6a, KRT6b, KRT6c, KRT7, KRT8, KRT71, KRT79 y KRT80), 3 genes de la fibra de tipo I (KRT31, KRT32 y KRT40) y 3 genes de la fibra de tipo II (KRT81, KRT82 y KRT83) (Zhidong et al.
Se identificaron un total de 48 PNSs de los cuales 14 PNSs se encuentran distribuidos en 8 genes de queratina de epitelio de tipo I (KRT9, KRT12, KRT13, KRT14, KRT16, KRT18, KRT20, KRT25); 23 PNSs distribuidos en los 8 genes de queratina de epitelio de tipo II (KRT1, KRT3, KRT5, KRT6a, KRT7, KRT8, KRT71, KRT80); 4 PNSs en los genes de queratina de fibra de tipo I (KRT31, KRT32, KIRT40) y 7 PNSs en los genes de queratina de fibra de tipo II (KRT81, KRT82, KRT83).
El analisis comparativo de secuencias genicas entre las cuatro especies estudiadas, indico que los genes KRT25, KRT10, KRT12, KRT20, KRT40, KRT31, KRT32, KRT13, KRT15, KRT19, KRT9, KRT14, KRT16 y KRT17 estan ubicados en el cromosoma 17, 11 y 19 de humano, ovino y cabra respectivamente; y en alpaca se encuentran en el scaffold 188 y 450 (Fig.
En el scaffold 450, los posibles PNSs de los genes KRT31, KRT32, KRT13, KRT9, KRT14y KRT16 formaron dos haplotipos, el 5'CTGAAG3' y el 5'TCAGGA3'.
It is caused by mutations in keratin genes KRT6a, KRT6b, KRT6c, KRT16, KRT17.
KRT6a, KRT6b, KRT6c, KRT16 and KRT17 expressed in the nail bed, palmoplantar skin, pilosebaceous unit and oral mucosa.4 Two main subtypes of PC are: 1) Jadassohn- Lewandowsky PC type 1 (PC-1) and, 2) Jackson- Lawler PC type 2 (PC-2).
PC is caused due to keratin gene mutations involving KRT6a, KRT6b, KRT6c, KRT16, KRT17.8 Based on these mutations, two major subtypes have been described:
Interestingly, 2 other KRTs, Krt16 and Krt6A or B, are also coregulated as part of an obligatory acidic/basic heteropolymer.
A leaked document form Samsung, published by Sammobile, suggests that the company is exploring an Android 4.4 Kitkat update (with base firmware KRT16) for multiple mid and low range Galaxy devices.
The other confirmed transcriptionally up-regulated genes may be associated with cervical disease: G1P2 (interferon-stimulated protein; 15-kDa) may be overproduced as a result of infection (24), and KRT14 and KRT16 (keratin 14 and 16) are produced at high concentrations in the keratinizing squamous epithelium of the cervix.
Patient identifier (b) Gene symbol (a) Pt 1 (c) Pt 2 Pt 3 Pt 4 Pt 5 CCNB1 +++ +++ + ++ +++ KRT14 +++ +++ + ++ +++ KARS +++ = + +++ + KRT16 ++ +++ = = +++ OAZ1 + +++ ++ ++ +++ SPINT2 + +++ + +++ +++ ZWINT ++ +++ +++ * +++ G1P2 +++ +++ ++ - - - +++ AURKB + 0 + = +++ CDCA8 ++ 0 + = + HPV16E7 +++ +++ 0 + 0 Patient identifier (b) Patients with up-regulated Gene symbol (a) Pt 6 Pt 7 Pt 8 gene, (d) n CCNB1 +++ + ++ 8 KRT14 = +++ + 7 KARS +++ +++ -- 6 KRT16 +++ +++ +++ 6 OAZ1 ++ = = 6 SPINT2 +++ = -- 6 ZWINT = +++ + 6 G1P2 - - 0 +++ 5 AURKB ++ 0 0 4 CDCA8 + 0 0 4 HPV16E7 +++ 0 0 4 (a) Genes listed were chosen for analysis by TagMan.
Pachyonychia congenita (PC) comprises a group of rare autosomal genodermatosis caused by mutation in any of the four genes KRT6A, KRT6B, KRT16 or KRT17.