KRT15

KRT15

A gene on chromosome 17q21.2 that encodes a type-I keratin, an intermediate filament protein that provides the structural integrity of epithelial cells.
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Se estudiaron 31 genes de queratina reportados para ovinos, cabras y humanos entre los cuales tenemos 12 genes del epitelio de tipo I (KRT9, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT20 y KRT25), 13 genes del epitelio de tipo II (KRT1, KRT2, KRT3, KRT4, KRT5, KRT6a, KRT6b, KRT6c, KRT7, KRT8, KRT71, KRT79 y KRT80), 3 genes de la fibra de tipo I (KRT31, KRT32 y KRT40) y 3 genes de la fibra de tipo II (KRT81, KRT82 y KRT83) (Zhidong et al.
El analisis comparativo de secuencias genicas entre las cuatro especies estudiadas, indico que los genes KRT25, KRT10, KRT12, KRT20, KRT40, KRT31, KRT32, KRT13, KRT15, KRT19, KRT9, KRT14, KRT16 y KRT17 estan ubicados en el cromosoma 17, 11 y 19 de humano, ovino y cabra respectivamente; y en alpaca se encuentran en el scaffold 188 y 450 (Fig.
Mendoza (2018) ubico mediante hibridacion fluorescente in situ (FISH) que el gen KRT15 esta ubicado en el cromosoma 16 q12-q13 en alpaca al igual que el scaffold 450, en consecuencia, los PNSs y genes ubicados en este scaffold se encuentran en el cromosoma 16 de alpaca (Fig.
To validate microarray data, we analysed SFN, FOXN1, Krt15, LHX2, CD34, and SOX9 gene expression by using mouse-predesigned oligos (Assay IDs: Mm.PT.58.42262048.g, Mm.PT.58.13135783, Mm.PT.58.5528981, Mm.PT.58.6480133, Mm.PT.58.8626728, and Mm.PT.58.42739087, resp., IDT[R]) and K6b-designed oligos (5'-CATCAAATACACCACCAGCG-3' (forward) and 5'-AAGCAGCCAAAAAGAGAAGC-3' (reverse)).
Epidermal stemness markers include integrin B1, p63, CD34, and Krt15 and are used, altogether with holoclone expansion assays, to evaluate the stem cells population in the skin [16].
Gene ontology: biological Genes p-Value process terms Cell cycle CCNB1, CCNB2, MNAT1, CDC2, 2.7 E-14 CDKN 1 A, CDKN3, CDKN2A, ANAPC1, CDK10 Cellular metabolism KRT15, KIF1B, ZNF697, 4.3E-13 PRG2, P2RY2,IMMP2L Growth factor and growth BMP-2, TCF[beta]1, VEGF, 1.2E-11 factor receptor activity BMP8B, CSF1, FCFR1, BMPR2, 1GF2R, PDCFB, TGFBR2, NRP1, CCR2 Biosynthetic process CEL, COL11A2, ACPP, MMP14, 1.8E-9 CACNB1, ALPL, CDH1, ITGA3, SERPINB10, TAF4B, ABCB10, IRF8 Cell proliferation ATF3, MK167, S100A6, FTH1, DHCR7 2.1E-8 Signal transduction MAP2K3, MAPK14, MAP3K10, BAMBI, NDRG2, ECM1, SMAD7 5.5E-7 Apoptosis MYC, P53AIP1, ZBTB16, BBC3, 1.3E-5 VHL, CASP3, APITD1 Table 5 KEGG pathway analysis.
In [Pb.sup.2+] treated samples, the expression of SOX 1 and NURR1, in early ectoderm markers, was considerably downregulated in BM-MSCs, while the expression of KRT15 was relatively stable among all sources.
In addition, genes, including Krt15, Krt14, N-cadherin, cadherin-3, nestin, SOD2, Wnt4, Notch-1, SPON1, IFITM1, ITM2A, CXCR4, DKK4, NGF, and its receptor TrkA, have been proposed as corneal limbal basal epithelial stem cell-specific markers [46-52].