KRT13

KRT13

A gene on chromosome 17q12-q21.2 that encodes a type-I intermediate filament keratin, which is expressed in corneal epithelia. KRT13 is paired with KRT4 and expressed in the suprabasal layers of non-cornified stratified epithelia.

Molecular pathology
KRT13 mutations are associated with autosomal dominant white sponge nevus.
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Se estudiaron 31 genes de queratina reportados para ovinos, cabras y humanos entre los cuales tenemos 12 genes del epitelio de tipo I (KRT9, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT20 y KRT25), 13 genes del epitelio de tipo II (KRT1, KRT2, KRT3, KRT4, KRT5, KRT6a, KRT6b, KRT6c, KRT7, KRT8, KRT71, KRT79 y KRT80), 3 genes de la fibra de tipo I (KRT31, KRT32 y KRT40) y 3 genes de la fibra de tipo II (KRT81, KRT82 y KRT83) (Zhidong et al.
Se identificaron un total de 48 PNSs de los cuales 14 PNSs se encuentran distribuidos en 8 genes de queratina de epitelio de tipo I (KRT9, KRT12, KRT13, KRT14, KRT16, KRT18, KRT20, KRT25); 23 PNSs distribuidos en los 8 genes de queratina de epitelio de tipo II (KRT1, KRT3, KRT5, KRT6a, KRT7, KRT8, KRT71, KRT80); 4 PNSs en los genes de queratina de fibra de tipo I (KRT31, KRT32, KIRT40) y 7 PNSs en los genes de queratina de fibra de tipo II (KRT81, KRT82, KRT83).
El analisis comparativo de secuencias genicas entre las cuatro especies estudiadas, indico que los genes KRT25, KRT10, KRT12, KRT20, KRT40, KRT31, KRT32, KRT13, KRT15, KRT19, KRT9, KRT14, KRT16 y KRT17 estan ubicados en el cromosoma 17, 11 y 19 de humano, ovino y cabra respectivamente; y en alpaca se encuentran en el scaffold 188 y 450 (Fig.
En el scaffold 450, los posibles PNSs de los genes KRT31, KRT32, KRT13, KRT9, KRT14y KRT16 formaron dos haplotipos, el 5'CTGAAG3' y el 5'TCAGGA3'.
Los genes KRT15, KRT19 y KRT17 se encuentran en el scaffold 450 alineados en tandem con los genes KRT31, KRT32, KRT13, KRT9, KRT14 y KRT16 (Fig.
A significant decline was seen with KRT1, KRT4, KRT13, and KRT77 while others were strongly upregulated (e.g., KRT35, KRT38, KRT72, KRT82, and KRT83) after redox stress.
Among these cytokeratin 13 (KRT13) and interleukin-1 receptor antagonist (IL1RN) were strongly downregulated in UCB tissue of smokers.
After a further washing step in TBS and a 20 min pretreatment in DAKO Real antibody diluent (DAKO, Glostrup, Denmark) the slides were incubated with mouse monoclonal anti-human KRT13 (Novocastra, Leica Biosystems, Wetzlar, Germany) or rabbit polyclonal anti-human IL1RN (Sigma-Aldrich, St.
The protein expression status of KRT13 and IL1RN was scored semiquantitatively (- none/very low (<10%), + low, ++ moderate, and +++ high).
Protein expression of KRT13 and IL1RN was compared between UCB tissue samples (groups 2-4) and controls (group 1).
Inconsistent results were seen in quadrant II for VAV3 in 0.05 [micro]M [MMA.sup.III]-exposed cells, KRT13 in 0.1 [micro]M [MMA.sup.III]-exposed cells, E2F1 in 0.1 and 0.2 [micro]M [MMA.sup.III]-exposed cells, and IL1R2 in 0.2 [micro]M [DMA.sup.III]-exposed cells; and in quadrant IV S100A8 in 0.5 [micro]M [DMA.sup.III]-exposed cells, IL8 in 0.2 [micro]M [DMA.sup.III]-exposed cells, and IL1R2 and IGFBP5 in MC-T2 cells.
The results of immunoblotting analysis confirmed the changes in gene expression at the protein level because protein levels of CDH1, HBEGF, and KRT13 in arsenical-treated cells and MC-T2 cells (Figure 5) agreed well with the mRNA levels measured by Q-PCR assay (Figure 4A).