El analisis comparativo de secuencias genicas entre las cuatro especies estudiadas, indico que los genes KRT25, KRT10, KRT12, KRT20, KRT40, KRT31, KRT32, KRT13, KRT15, KRT19, KRT9, KRT14, KRT16 y KRT17 estan ubicados en el cromosoma 17, 11 y 19 de humano, ovino y cabra respectivamente; y en alpaca se encuentran en el scaffold 188 y 450 (Fig.
De los 31 genes, en 9 genes (KRT10, KRT15, KRT17, KRT19, KRT2, KRT4, KRT6b, KRT6c y KRT79) no se pudo identificar ningun PNS exonico o intronico.
Conversely, compartimentalization and expression of the marker of differentiation, such as KRT10, rather weak in the suprabasal layer epidermis of IMQ-treated mice, were restored by treatment with the drug (Figure 5).
Immunohistochemistry analysis of mouse skin left untreated (i), IMQ-treated (ii), and IMQ-treated in the presence of tofacitinib (iii) shows reduction of positive CD3, LY6G, Ki67, CD11c, and CD11b cells and an increase of KRT10 in the epidermis after tofacitinib treatment.