KRT10


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KRT10

A gene on chromosome 17q21 that encodes a type-I (acidic) member of the cytokeratin family, which belongs to the superfamily of intermediate filaments, that with actin microfilaments and microtubules forms the epithelial cell cytoskeleton.

Molecular pathology
KRT10 mutations cause epidermolytic hyperkeratosis.
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References in periodicals archive ?
Epidermolytic acanthoma of the genitalia does not show mutations in KRT1 or KRT10. Am J Dermatopathol.
Verruciform and Condyloma-like Squamous Proliferations in the Anogenital Region
El analisis comparativo de secuencias genicas entre las cuatro especies estudiadas, indico que los genes KRT25, KRT10, KRT12, KRT20, KRT40, KRT31, KRT32, KRT13, KRT15, KRT19, KRT9, KRT14, KRT16 y KRT17 estan ubicados en el cromosoma 17, 11 y 19 de humano, ovino y cabra respectivamente; y en alpaca se encuentran en el scaffold 188 y 450 (Fig.
De los 31 genes, en 9 genes (KRT10, KRT15, KRT17, KRT19, KRT2, KRT4, KRT6b, KRT6c y KRT79) no se pudo identificar ningun PNS exonico o intronico.
Identificacion bioinformatica de Polimorfismos de Nucleotido Simple (PNSs) en genes candidatos para las caracteristicas de la fibra en alpacas (Vicugna pacos)
Conversely, compartimentalization and expression of the marker of differentiation, such as KRT10, rather weak in the suprabasal layer epidermis of IMQ-treated mice, were restored by treatment with the drug (Figure 5).
Immunohistochemistry analysis of mouse skin left untreated (i), IMQ-treated (ii), and IMQ-treated in the presence of tofacitinib (iii) shows reduction of positive CD3, LY6G, Ki67, CD11c, and CD11b cells and an increase of KRT10 in the epidermis after tofacitinib treatment.
Selective Immunomodulation of Inflammatory Pathways in Keratinocytes by the Janus Kinase (JAK) Inhibitor Tofacitinib: Implications for the Employment of JAK-Targeting Drugs in Psoriasis

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