KRT1

KRT1

A gene on chromosome  12q13.13 that encodes a type-II cytokeratin that is specifically co-expressed in the spinous and granular layers of the epidermis with KRT10.
 
Molecular pathology
KRT1 mutations are associated with bullous congenital ichthyosiform erythroderma, ichthyosis hystrix and Curth-Macklin type.
References in periodicals archive ?
Unlike epidermolytic ichthyosis, which is caused by germline mutation in KRT1 or KRT10, somatic mutations in these genes have not been found in epidermolytic acanthomas.
Epidermolytic acanthoma of the genitalia does not show mutations in KRT1 or KRT10.
Se estudiaron 31 genes de queratina reportados para ovinos, cabras y humanos entre los cuales tenemos 12 genes del epitelio de tipo I (KRT9, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT20 y KRT25), 13 genes del epitelio de tipo II (KRT1, KRT2, KRT3, KRT4, KRT5, KRT6a, KRT6b, KRT6c, KRT7, KRT8, KRT71, KRT79 y KRT80), 3 genes de la fibra de tipo I (KRT31, KRT32 y KRT40) y 3 genes de la fibra de tipo II (KRT81, KRT82 y KRT83) (Zhidong et al.
Se identificaron un total de 48 PNSs de los cuales 14 PNSs se encuentran distribuidos en 8 genes de queratina de epitelio de tipo I (KRT9, KRT12, KRT13, KRT14, KRT16, KRT18, KRT20, KRT25); 23 PNSs distribuidos en los 8 genes de queratina de epitelio de tipo II (KRT1, KRT3, KRT5, KRT6a, KRT7, KRT8, KRT71, KRT80); 4 PNSs en los genes de queratina de fibra de tipo I (KRT31, KRT32, KIRT40) y 7 PNSs en los genes de queratina de fibra de tipo II (KRT81, KRT82, KRT83).
The quantitative trait locus affecting wool strength in Romney sheep is located on chromosome 11, and is linked to KRT1.2, B2A, and B2C (high-sulphur wool matrix protein B2A and B2C) [13].
(b) Keratin 1 (KRT1), loricrin, and p63 were analysed by WB by using protein lysates obtained from keratinocyte cultures grown at 100% confluency (0d) or for additional four days (4d), in the presence or absence of tofacitinib and IFN-[gamma] or IL-22.
Nonetheless, multiple genes participating in the inflammatory response (IL10, KRT1, PELI1, and PLGYRP1) were present.
Human Retinol binding protein 4 (RBP4), Kininogen 1 (KNG1), Keratin 1 (KRT1) ELISA kit (Cusabio Biotech, Wuhan, Hubei, China), Human Serum amyloid protein A (SAA) ELISA kit (Abcam, Cambridge, MA, USA), and Human Myeloperoxidase (MPO) ELISA kit (Uscn Life Science, Wuhan, Hubei, China) were applied to determine the concentration of proteins in each serum sample in validation set (30 samples in EH group and 30 samples in TJT treated group).
Among these identified AECA-targeting proteins, Keratin 1 (KRT1) become more interesting because of its gene polymorphism [24] and it appears expressed on the surface of endothelial cells [25].
A significant decline was seen with KRT1, KRT4, KRT13, and KRT77 while others were strongly upregulated (e.g., KRT35, KRT38, KRT72, KRT82, and KRT83) after redox stress.
For the SID-MRM analysis, we first synthesized stable-isotope standard (SIS) peptides (>95% purity) for 15 proteins (APLP2, APOA4, APOH, B3GNT1, C4B, C5, C7, CD14, CLU, FN1, GSN, ITIH2, KRT1, SERPINF1, and VTN).