KRT1

KRT1

A gene on chromosome  12q13.13 that encodes a type-II cytokeratin that is specifically co-expressed in the spinous and granular layers of the epidermis with KRT10.
 
Molecular pathology
KRT1 mutations are associated with bullous congenital ichthyosiform erythroderma, ichthyosis hystrix and Curth-Macklin type.
References in periodicals archive ?
KRT1 is a major epithelial keratin and western blotting confirmed its significantly lower expression after periodic oxidative challenge (Figure 6(b)(III)).
Genellikle palmoplantar tutulum KRT1 mutasyonu olanlarda daha belirgindir cunku palmoplantar bolgede keratin 9, anormal keratin 10 ekspresyonunu kompanse eder bu nedenle keratin 10 mutasyonu gosterenlerde palmoplantar tutulum gorulmez ancak KRT1 kritik oneme sahiptir.
KRT1 ve KRT10 mutasyonlari diger iktiyotik fenotiplere neden olabilir.