KRAS


Also found in: Dictionary, Acronyms, Encyclopedia, Wikipedia.
Related to KRAS: Moravsky Kras

KRAS

A Kirsten ras oncogene homolog from the mammalian ras gene family on chromosome 12p12.1, which encodes a small GTPase in which a single amino acid substitution results in a transforming protein.

Molecular pathology
The KRAS transforming protein has been linked to various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas, colorectal carcinoma, acute myelogenous leukaemia, juvenile myelomonocytic leukaemia, gastric cancer, pilocytic astrocytoma, Noonan syndrome type 3, and cardiofaciocutaneous syndrome
References in periodicals archive ?
The "AMP KRAS vaccine" administration and resulting immune response yields robust activation against all common mutations in the KRAS protein compared to low or undetectable responses generated by soluble or benchmark treatments which fail to effectively reach the lymph nodes.
(25) The current expanded study population showed a similar mutation rate in each gene, AKT1 mutations in 5 specimens (0.4%), BRAF mutations in 78 specimens (6.5%), EGFR mutations in 226 specimens (19%), ERBB2 mutations in 17 specimens (1.3%), KRAS mutations in 428 specimens (35%), NRAS mutations in 12 specimens (1.0%), and PIK3CA mutations in 47 specimens (3.9%).
KRA has a zero-tolerance policy on corruption, he said.
The limit of detection for KRAS mutations was evaluated by serially diluting cfDNA from the mutated pancreatic cancer cell line, CFPAC-1, producing a standard curve with a low-end fractional abundance of KRAS mutations of 0.01%.
PIK3CA mutations were found in a total of five cases (Table 2), all of which showed KRAS mutations as well.
This rare case of metastatic colorectal cancer with concomitant KRAS and BRAF mutations had several unusual features including young age of presentation with no risk factors, harboring concomitant KRAS and BRAF, and rapid progression of disease to death within 3 months of the onset of disease.
Kirsten rat sarcoma viral oncogene homolog (KRAS) is involved in G-protein-mediated signal transduction.1
KRAS is a signaling molecule -- a protein switch that triggers a cascade of molecular events that tell cells to grow and survive.
Figure 1 shows the amplified product of exon 1 of Kras gene (163bp).
Introduction of the therascreen KRAS test provides an FDA-approved diagnostic available for making treatment decisions for colorectal cancer patients.
Researchers have known that mutations in the Kras gene are what cause pancreatic cancer to develop.