In human importin [alpha], for example, there exists an [alpha]1 subfamily (importin [alpha]5 (KPNA1), [alpha]6 (KPNA5), and [alpha]7 (KPNA6)), [alpha]2 subfamily (importin [alpha]1 (KPNA2) and [alpha]8 (KPNA7)), and [alpha]3 subfamily (importin [alpha]3 (KPNA4) and [alpha]4 (KPNA3)) (Fig.
To avoid confusion, we primarily use the terms KPNA1 to KPNA7 below to refer to human and mouse importin subtypes, because the same term is used for human and mouse homologues.
On the other hand, knocking out KPNA7 results in reduced reproductivity and fetal lethality in females.
Among the importin [alpha] subtypes, KPNA7 is the newest member and is specifically expressed in ovaries and mature oocytes, (72, 84, 103) where it functions as an NLS receptor.
(2010) Novel importin-[alpha] family member Kpna7 is required for normal fertility and fecundity in the mouse.
(2014) Autosomal recessive mutations in nuclear transport factor KPNA7 are associated with infantile spasms and cerebellar malformation.
(2012) KPNA7, an oocyte-and embryo-specific karyopherin alpha subtype, is required for porcine embryo development.
(2017) Search for KPNA7 cargo proteins in human cells reveals MVP and ZNF414 as novel regulators of cancer cell growth.
(2010) Karyopherin [alpha]7 (KPNA7), a divergent member of the importin [alpha] family of nuclear import receptors.