KPNA6

KPNA6

A gene on chromosome 1p35.1 that encodes an alpha subunit of karyopherin, which plays a key role in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats; the complex is then translocated through the pore by an energy-requiring, Ran-dependent mechanism.
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In human importin [alpha], for example, there exists an [alpha]1 subfamily (importin [alpha]5 (KPNA1), [alpha]6 (KPNA5), and [alpha]7 (KPNA6)), [alpha]2 subfamily (importin [alpha]1 (KPNA2) and [alpha]8 (KPNA7)), and [alpha]3 subfamily (importin [alpha]3 (KPNA4) and [alpha]4 (KPNA3)) (Fig.
(85) Although KPNA6 knockout mice were viable, KPNA6-null oocytes showed a complete arrest at the two-cell embryo stage after fertilization, (86) demonstrating that it has an important role in the very early phases of development.
Human Mouse KPNA1 Importin [alpha]5 KPNA1 Importin [alpha]1 KPNA2 Importin [alpha]1 KPNA2 Importin [alpha]2 KPNA3 Importin [alpha]4 KPNA3 Importin [alpha]3 KPNA4 Importin [alpha]3 KPNA4 Importin [alpha]4 KPNA5 Importin [alpha]6 KPNA6 Importin [alpha]7 KPNA6 Importin [alpha]6 KPNA7 Importin [alpha]8 KPNA7 Importin [alpha]8