KPNA4

KPNA4

A gene on chromosome 3q25.33 that encodes an alpha subunit of karyopherin, which plays a key role in nuclear protein import as an adapter protein for nuclear receptor KPNB1. It binds specifically and directly to substrates containing nuclear localisation sequence (NLS) motif.
References in periodicals archive ?
In human importin [alpha], for example, there exists an [alpha]1 subfamily (importin [alpha]5 (KPNA1), [alpha]6 (KPNA5), and [alpha]7 (KPNA6)), [alpha]2 subfamily (importin [alpha]1 (KPNA2) and [alpha]8 (KPNA7)), and [alpha]3 subfamily (importin [alpha]3 (KPNA4) and [alpha]4 (KPNA3)) (Fig.
For example, the expression patterns of importin [alpha] subtypes were shown to change during cell differentiation processes, and, more importantly, its modulation clearly affects cell differentiation processes such as the differentiation of embryonic stem cells into neural cells (KPNA1 (73)), myoblasts into myotubes (KPNA2 (77)), or maturation of oligodendrocyte progenitors (KPNA1, (80) KPNA4 (78)).
Intriguingly, a comparison of KPNA1, KPNA4, and KPNA6 knockout mice revealed that KPNA6 knockout mice are highly resistant to infection with influenza viruses, (87) highlighting the importance of importin [alpha] as a determinant of pathogenicity.
NS5 protein of JEV can inhibit the activation of IRF3 and NF-[kappa]B, then reduce the amount of type I IFN and promote JEV replication process, which results from NS5 protein interaction with KPNA3 and KPNA4 [63].
Several proteins were differentially expressed, which included karyopherin alpha 4 (KPNA4) overexpressed only in paralytic rabies, calcium calmodulin dependent kinase 2 alpha (CAMK2A) which was upregulated in paralytic rabies, and glutamate ammonia ligase (GLUL) which was overexpressed both in paralytic and encephalitic rabies.