KPNA3

KPNA3

A gene on chromosome 13q14.3 that encodes an alpha subunit of karyopherin, which plays a key role in nuclear protein import as an adapter protein for nuclear receptor KPNB1. It binds specifically and directly to substrates containing nuclear localisation sequence (NLS) motif.
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References in periodicals archive ?
In human importin [alpha], for example, there exists an [alpha]1 subfamily (importin [alpha]5 (KPNA1), [alpha]6 (KPNA5), and [alpha]7 (KPNA6)), [alpha]2 subfamily (importin [alpha]1 (KPNA2) and [alpha]8 (KPNA7)), and [alpha]3 subfamily (importin [alpha]3 (KPNA4) and [alpha]4 (KPNA3)) (Fig.
Importin [alpha] molecules (KPNA1, KPNA2, and KPNA3) also exist in cytoplasmic stress granules (SGs) that were induced by arsenite or heat shock.
NS5 protein of JEV can inhibit the activation of IRF3 and NF-[kappa]B, then reduce the amount of type I IFN and promote JEV replication process, which results from NS5 protein interaction with KPNA3 and KPNA4 [63].
miR-26a-5p was found to be suppressed by IL-1[beta]-mediated NF-[kappa]B activation, thereby allowing induction of its direct target iNOS in cartilage [60]; in addition, miR-26a, alongside with miR-26b, was found to modulate NF-[kappa]B p65 translocation via repression of karyopherin subunit alpha 3 (KPNA3) [61].