KLRG1 | definition of KLRG1 by Medical dictionary
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KLRG1 A gene on chromosome 12p13.31 that encodes a C-type lectin domain protein which inhibits natural killer (NK)- and T-cell functions by binding to their non-MHC ligands. KLRG1 may mediate missing self-recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells. KLRG1 expression is induced by pathogens and viruses.
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References in periodicals archive
Voehringer et al., "Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1
)," Experimental Gerontology, vol.
e um tipo de receptor capaz de bloquear a funcao efetora de linfocitos T citotoxicos (CD3+CD8+) e de celulas natural killer (NK).
Koschella et al., "Frequent expression of the natural killer cell receptor KLRG1
in human cord blood T cells: correlation with replicative history," European Journal of Immunology, vol.
Thus, increased expression of KLRG1
by virus-specific CD8 T cells occurs mainly during persistent antigen stimulation .