On the other hand, results obtained with exome chips (ftp://share.sph.umich.edu/exomeChip/Proposed Content/codingContent) have indicated the occurrence of stop codons in several KLK genes, including KLK4, KLK9, KLK10, and KLK14.
 Human genes: KLK3, kallikrein-related peptidase 3; TERT, telomerase reverse transcriptase; FGFR2, fibroblast growth factor receptor 2; TBBX3, T-box protein 3; KLK15, kallikrein-related peptidase 15; KLK2, kallikrein-related peptidase 2; KLK1, kallikrein-related peptidase 1; ACPT, acid phosphatase, testicular; GPR32, G protein-coupled receptor 32; INS, insulin; KLK4, kallikrein-related peptidase 4; KLK9, kallikrein-related peptidase 9; KLK10, kallikrein-related peptidase 10; KLK14, kallikrein-related peptidase 14.
These genes include angiogenic/vascular cell growth factors (VEGF, PLGF, ADM, ANGPT2, TGFB2), vasoactive serine proteases (KLK2, KLK6, KLK9
, KLK22), and vascular endothelial receptors (IL17R, BDKRB1, ENG, GNA13).
KLK9 has previously been shown to be expressed in the brain, liver, lung, small intestine, spinal cord, thymus, trachea, prostate, testis, and breast at the mRNA level (29) and primarily expressed in the testis and seminal vesicle at the protein level (30).
The secretion of KLK9 into biological fluids has not been studied to date.
The expanded human kallikrein gene family: locus characterization and molecular cloning of a new member, KLK-L3 (KLK9).
Previously, several other kallikreins, including KLK4, KLK5, KLK6, KLK7, KLK8, KLK9
, KLK10, KLK11, KLK14, and KLK15, have been associated with various forms of malignancy and especially cancers of the ovary, breast, prostate, and testis [reviewed in Refs.
More recently, KLK9 has been shown to be a marker of favorable prognosis for the same malignancy (66).
Quantitative expression of the human kallikrein gene 9 (KLK9) in ovarian cancer: a new independent and favorable prognostic marker.
(a) Official Name when first First GenBank First kallikrein cloned submission publication name KLK4 Prostase AF113141 (24) KLK5 KLK-L2 AF135028 (23) KLK6 Neurosin D78203 (mRNA) (73) AF149289 (Full gene) (22) KLK7 HSCCE (b) L33404 (mRNA) (74) AF166330 (Full gene) (13) KLKS Neuropsin AB009849 (75) KLK9 KLK-L3 AF135026 (76) KLK10 NES1 NM 002776 (mRNA) (58) AF055481 (Full gene) (77) KLK11 TLSP ABO12917 (mRNA) (78) AF164623 (Full gene) (79) KLK12 KLK-L5 AF135025 (28) KLK13 KLK-L4 AF135024 (14) KLK14 KLK-L6 AF161221 (27) KLK15 KLK15 AF242195 (7) (a) A brief history describing the discovery of the three classic kallikreins has been published in a recent review (54).
New gene Previous gene New protein symbol (a,b) symbol(s) symbol KLK1 KLK1 hK1 KLK3 KLK3 hK3 KLK2 KLK2 hK2 KLK4 PRSS17, KLK-L1, KLK4 hK4 KLK5 KLK-L2 hK5 KLK6 PRSS9 hK6 KLK7 PRSS6 hK7 KLKS PRSS19 hK8 KLK9
KLK-L3 hK9 KLK10 PRSSL1, hK10 KLK11 PRSS20 hK11 KLK12 KLK-L5 hK12 KLK13 KLK-L4 hK13 KLK14 KLK-L6 hK14 New gene symbol (a,b) Other protein names/symbols KLK1 Pancreatic/renal kallikrein, hPRK KLK3 Prostate-specific antigen, PSA KLK2 Human glandular kallikrein 1, hGK-1 KLK4 Prostase, KLK-L1 protein, EMSP1 KLK5 KLK-L2 protein, HSCTE KLK6 Zyme, protease M, neurosin KLK7 HSCCE KLKS Neuropsin, ovasin, TADG-14 KLK9
KLK-L3 protein KLK10 NES1 protein KLK11 TLSP/hippostasin KLK12 KLK-L5 protein KLK13 KLK-L4 protein KLK14 KLK-L6 protein New gene GenBank symbol (a,b) Accession No.