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Here, we examined the expression of FLG and related serine proteases (KLK5, KLK7, matriptase, and CAP1), cysteine protease caspase-14, and LEKTI by immunohistochemical staining in acute and chronic lesions of AD.
Expression of FLG, LEKTI, caspase14, KLK7, KLK5, matriptase, and CAP1 proteins was evaluated by Western blotting.
The amounts of 18S rRNA and mRNAs encoded by KLK5, KLK6, KLK7, KLK10,
The KLK8 mRNAs were considered alone or as a ratio with the KLK5, KLK6, KLK7, KLK10, KLK11, KLK13, or KLK14 mRNA in the same samples.
The highest concentrations of KLK7 were found in skin (adult and fetal).
Three independent groups have found KLK7 mRNA to be significantly up-regulated in ovarian cancer (14, 20, 21).
Recent reports have linked high KLK7  expression to a significantly poorer prognosis in ovarian and breast cancer, indicating that KLK7 may be a potent prognostic marker for ovarian and breast cancer (12-14).
Because the HSCCE gene (a) is located next to other members in the human kallikrein family, (b) has the same genomic organization and intron phase as other members of this family and (c) has significant homology to other members of the family in both the DNA and amino acid sequences (7), HSCCE is now considered to be a member of the human kallikrein family and has been given a new name, KLK7 for the gene and human kallikrein 7 (hK7) for the protein (8).
Fine mapping of the area indicates that KLK6 lies between the KLK5 and KLK7 genes (9).
Previously, several other kallikreins, including KLK4, KLK5, KLK6, KLK7, KLK8, KLK9, KLK10, KLK11, KLK14, and KLK15, have been associated with various forms of malignancy and especially cancers of the ovary, breast, prostate, and testis [reviewed in Refs.
KLK7 is up-regulated in ovarian cancer (62), and KLK4 and KLK5 are indicators of poor prognosis of ovarian cancer (63-65).
New gene Previous gene New protein symbol (a,b) symbol(s) symbol KLK1 KLK1 hK1 KLK3 KLK3 hK3 KLK2 KLK2 hK2 KLK4 PRSS17, KLK-L1, KLK4 hK4 KLK5 KLK-L2 hK5 KLK6 PRSS9 hK6 KLK7 PRSS6 hK7 KLKS PRSS19 hK8 KLK9 KLK-L3 hK9 KLK10 PRSSL1, hK10 KLK11 PRSS20 hK11 KLK12 KLK-L5 hK12 KLK13 KLK-L4 hK13 KLK14 KLK-L6 hK14 New gene symbol (a,b) Other protein names/symbols KLK1 Pancreatic/renal kallikrein, hPRK KLK3 Prostate-specific antigen, PSA KLK2 Human glandular kallikrein 1, hGK-1 KLK4 Prostase, KLK-L1 protein, EMSP1 KLK5 KLK-L2 protein, HSCTE KLK6 Zyme, protease M, neurosin KLK7 HSCCE KLKS Neuropsin, ovasin, TADG-14 KLK9 KLK-L3 protein KLK10 NES1 protein KLK11 TLSP/hippostasin KLK12 KLK-L5 protein KLK13 KLK-L4 protein KLK14 KLK-L6 protein New gene GenBank symbol (a,b) Accession No.
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