Among these KLKs, corneocyte desquamation is mainly conducted by KLK5, KLK7
, and KLK14 .
Here, we examined the expression of FLG and related serine proteases (KLK5, KLK7
, matriptase, and CAP1), cysteine protease caspase-14, and LEKTI by immunohistochemical staining in acute and chronic lesions of AD.
Correlative studies have already provided evidence that five other protein members of KLK family (KLK4, KLK5, KLK7
, KLK8, and KLK10) were abundantly expressed in head and neck squamous cell carcinoma, showing diagnostic value .
The amounts of 18S rRNA and mRNAs encoded by KLK5, KLK6, KLK7
The highest concentrations of KLK7
were found in skin (adult and fetal).
Further evidence has shown that human tissue kallikrein 7 (KLK7
)  mRNA is significantly up-regulated in ovarian tumors (20, 21).
Recent reports have linked high KLK7
 expression to a significantly poorer prognosis in ovarian and breast cancer, indicating that KLK7
may be a potent prognostic marker for ovarian and breast cancer (12-14).
The HSCCE gene (KLK7
) encodes for a 253-amino acid polypeptide containing a predicted signal peptide of 22 amino acids and a propeptide of 7 amino acids (4).
Fine mapping of the area indicates that KLK6 lies between the KLK5 and KLK7
Previously, several other kallikreins, including KLK4, KLK5, KLK6, KLK7
, KLK8, KLK9, KLK10, KLK11, KLK14, and KLK15, have been associated with various forms of malignancy and especially cancers of the ovary, breast, prostate, and testis [reviewed in Refs.
is up-regulated in ovarian cancer (62), and KLK4 and KLK5 are indicators of poor prognosis of ovarian cancer (63-65).
New gene Previous gene New protein symbol (a,b) symbol(s) symbol KLK1 KLK1 hK1 KLK3 KLK3 hK3 KLK2 KLK2 hK2 KLK4 PRSS17, KLK-L1, KLK4 hK4 KLK5 KLK-L2 hK5 KLK6 PRSS9 hK6 KLK7
PRSS6 hK7 KLKS PRSS19 hK8 KLK9 KLK-L3 hK9 KLK10 PRSSL1, hK10 KLK11 PRSS20 hK11 KLK12 KLK-L5 hK12 KLK13 KLK-L4 hK13 KLK14 KLK-L6 hK14 New gene symbol (a,b) Other protein names/symbols KLK1 Pancreatic/renal kallikrein, hPRK KLK3 Prostate-specific antigen, PSA KLK2 Human glandular kallikrein 1, hGK-1 KLK4 Prostase, KLK-L1 protein, EMSP1 KLK5 KLK-L2 protein, HSCTE KLK6 Zyme, protease M, neurosin KLK7
HSCCE KLKS Neuropsin, ovasin, TADG-14 KLK9 KLK-L3 protein KLK10 NES1 protein KLK11 TLSP/hippostasin KLK12 KLK-L5 protein KLK13 KLK-L4 protein KLK14 KLK-L6 protein New gene GenBank symbol (a,b) Accession No.