KLK6

KLK6

A gene on chromosome 19q13.3 that encodes a serine protease that catalyses amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins (such as fibronectin, laminin, vitronectin and collagen). It may be involved in regulating axon outgrowth following spinal cord injury. KLK6 may play a role in invasion and metastasis.

Molecular pathology
KLK6 degrades alpha-synuclein, preventing its polymerisation, suggesting a role in the pathogenesis of Parkinson disease and other synucleinopathies.
References in periodicals archive ?
PPAR[delta] activates PPRE-containing genes associated with metabolism (Olah, Ptgs2, Pla2, and Pld), invasion (Mmp12, Klk6), and inflammation (S100a8/9, Saa1/2/3).
TaqMan gene expression assays used were Hs00160519_m1 (kallikrein 6, KLK6), Hs00173611_m1 (kallikrein 10, KLK10), Hs00234579_m1 (matrix metalloproteinase 9, MMP9) and Hs99999905_m1 (glyceraldehyde 3-phosphate dehydrogenase, GAPDH).
A list of candidate biomarkers was chosen according to a set of criteria, highlighting KLK6, a protein that belongs to the 15-member KLK family in which KLK3 (also known as prostate-specific antigen) is the most useful marker for the early detection of prostate cancer.
KLK6, the protein encoded by the Kallikrein-related peptidase 6 (KLK6) [5] gene, is a promising biomarker that is frequently overexpressed at the mRNA and protein levels in tissues and fluids derived from patients with ovarian cancer (OCa) and implicated in a variety of normal physiological processes (3).
Scarisbrick previously found elevated levels of "KLK6" (a newly identified member of the kallikrein enzyme family) in areas of damage found in tissue samples from people with MS.
These genes include angiogenic/vascular cell growth factors (VEGF, PLGF, ADM, ANGPT2, TGFB2), vasoactive serine proteases (KLK2, KLK6, KLK9, KLK22), and vascular endothelial receptors (IL17R, BDKRB1, ENG, GNA13).
Recent work has demonstrated roles for KLK5 and 7 in skin desquamation (7), and for KLK6 in the brain (8).
(30) found no overexpression of the 15 tissue kallikreins in breast cancer tissue compared with healthy breast tissue and down-regulation of the expression of at least 4 tissue kallikrein genes (KLK5, KLK6, KLK8, and KLK10) in breast cancer tissue.
For example, we found that KLK6 and KLK13 have a splice variant with 3'-coding exon 3 extension by ~100 by (close to the length of the retained intron III in the genes examined here).
The human kallikrein 6 (KLK6)[3] gene, which encodes for hK6 protein, was cloned independently by three groups.