KLK5

A gene on chromosome 19q13.33 that encodes a protein thought to be involved in desquamation; it is expressed in the skin, breast, brain and testes.

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This upregulation was found to induce the production of cathelicidin and KLK5 so as to mediate the activation of proinflammatory and antimicrobial immune responses [15].

ATF4 Involvement in TLR4 and LOX-1-Induced Host Inflammatory Response to Aspergillus fumigatus Keratitis

Among these KLKs, corneocyte desquamation is mainly conducted by KLK5, KLK7, and KLK14 [47].

Zinc in Keratinocytes and Langerhans Cells: Relevance to the Epidermal Homeostasis

This process needs another enzyme KLK5. This is a new finding that answers a long standing question as to why diabetics have more DPP4," Chakrabarti told IANS.

Scientists stumble upon potential drug target for diabetes

Studies looking at other proinflammatory agents in the skin of patients affected by rosacea found that there is excessive production of both cathelicidin (LL-37) and kallikrein (KLK5), the serine protease responsible for its cleavage [2123].

Ocular Rosacea Causing Corneal Melt in an African American Patient and a Hispanic Patient

Kriegel AJ, a member of our research group, had demonstrated that Kalliken5 (KLK5), a (chymo) trypsin-like proteinase that mediates degradation of many extracellular matrix proteins, was a target of miR-382 in the mouse UUO model.

miR-382 Contributes to Renal Tubulointerstitial Fibrosis by Downregulating HSPD1

They assessed cathehcidin and serine protease by analyzing stratum corneum samples obtained with adhesive tape, and quantified expression of the cathehcidin antimicrobial peptide (CAMP) gene, the matrix metallopeptidase 9 (MMP9) gene, and the serine protease-encoding KLK5 gene by studying small skin biopsies.

Study eyes markers of doxycycline response in papulopustular rosacea

Here, we examined the expression of FLG and related serine proteases (KLK5, KLK7, matriptase, and CAP1), cysteine protease caspase-14, and LEKTI by immunohistochemical staining in acute and chronic lesions of AD.

T Helper 1 and T Helper 2 Cytokines Differentially Modulate Expression of Filaggrin and its Processing Proteases in Human Keratinocytes

In PP rosacea, serine protease kallikrein-5 (KLK5) and two abnormal cathelicidin peptides (LL-37 and FA-29) are upregulated in the skin and induce erythema and vascular dilatation when injected in mouse skin.

Assessment of tachykinin receptor 3' gene polymorphism rs3733631 in rosacea

Correlative studies have already provided evidence that five other protein members of KLK family (KLK4, KLK5, KLK7, KLK8, and KLK10) were abundantly expressed in head and neck squamous cell carcinoma, showing diagnostic value [45].

Identification of human tissue kallikrein 6 as a potential marker of laryngeal cancer based on the relevant secretory/releasing protein database

The amounts of 18S rRNA and mRNAs encoded by KLK5, KLK6, KLK7, KLK10,

Alternative splicing variant of kallikrein-related peptidase 8 as an independent predictor of unfavorable prognosis in lung cancer

In patients with rosacea, this cathelicidin appears to result from abnormal activity of serine protease kallikrein 5 (KLK5; also known as stratum corneum tryptic enzyme).

Rosacea: pathogenesis and therapy

In some cases KLK cascades have been partially delineated, such as in seminal plasma (KLK2, 3, 5) (4) and skin (KLK5, 7, 14) (5,6).