KLK5

KLK5

A gene on chromosome 19q13.33 that encodes a protein thought to be involved in desquamation; it is expressed in the skin, breast, brain and  testes.
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Kallikrein-related peptidase 5 or KLK5 cleaves off the DPP4 present on the surface of Th17 cells and the freely circulating DPP4 starts piling up in blood.
They assessed cathehcidin and serine protease by analyzing stratum corneum samples obtained with adhesive tape, and quantified expression of the cathehcidin antimicrobial peptide (CAMP) gene, the matrix metallopeptidase 9 (MMP9) gene, and the serine protease-encoding KLK5 gene by studying small skin biopsies.
Expression of FLG, LEKTI, caspase14, KLK7, KLK5, matriptase, and CAP1 proteins was evaluated by Western blotting.
It is possible that the polymorphism at the adjacent TACR3 may be somehow involved in increasing expression of TLR2 in rosacea and therefore in upregulation of KLK5 in a calcium-dependent manner; possibly PP rosacea patients overreact, resulting in the histogenesis ofrosacea papules and pustules, even though bacterial diversity and quantities are similar in rosacea lesions and in normal skin [34].
Recent experimental findings suggest that high levels of TLR2 in skin increases susceptibility to microbial and environmental stimuli, increasing cathelicidin and KLK5 expression.
Recent work has demonstrated roles for KLK5 and 7 in skin desquamation (7), and for KLK6 in the brain (8).
Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers.
When we performed PCR on 36 healthy human tissue samples, we observed a second band, higher than the one expected for the classical form for the genes KLK1, KLK2, KLK5, and KLK15.
Fine mapping of the area indicates that KLK6 lies between the KLK5 and KLK7 genes (9).
Previously, several other kallikreins, including KLK4, KLK5, KLK6, KLK7, KLK8, KLK9, KLK10, KLK11, KLK14, and KLK15, have been associated with various forms of malignancy and especially cancers of the ovary, breast, prostate, and testis [reviewed in Refs.