KLK2

KLK2

A gene on chromosome 19q13.33 that encodes a serine protease with diverse physiological functions, which may also have a role in carcinogenesis. KLK2 is highly expressed in prostate cancer and may serve as a prognostic marker for prostate cancer.
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Bu genler; androjen yolu (AZGP1, KLK2, SRD5A2, RAM13 C), proliferasyon (TPX2), hucresel organizasyon (FLNC, GSN, TPM2, GSTM2) ve stromal yanit (BGN, COLIA, SFRP4) genleridir.
Five reference genes and 12 cancer genes represent pathways in prostate tumorigenesis in OncofypeDX Prostate Cancer Assay, which includes AZGP1, KLK2, SRD5A2, FAM13C, FLNC, GSN, TPM2, GSTM2, TPX2, BGN, COL1A1, and SFRP4.
To address this question, we examined the relationship between SNPs in KLK2 and KLK3 and concentrations of hK2 and PSA in serum and seminal plasma by use of a population-based cohort of young men in whom prostate conditions are very rare.
The genes that were more highly expressed in carcinomas treated with androgen ablation agents included those encoding AR and steroid biosynthetic enzymes, as well as a suite of genes that have been previously shown to be targets of AR or have been implicated as being regulated by it, including the gene encoding PSA (kallikrein-related peptidase 3), KLK3, and KLK2, as well as DBI, FASN, IL6, SERPINB5, TGFBR3, TMPRSS2, TUBA1, HOXC6, TRG ,and FOLH1.
PSA and human kallikrein 2 are closely related products of human kallikrein genes KLK3 and KLK2, respectively.
Internal diagnostic projects include a prostate cancer diagnostic test, based on alternatively spliced isoforms of PSA and KLK2, and a blood-based diagnostic test for colon cancer.
12) identified 555 polymorphic loci within the region containing KLK3 and the neighboring genes KLK15 and KLK2, including 116 novel SNPs, 182 novel insertion-deletion (indel) polymorphisms, and 257 previously described loci.
The National Cancer Institute study identified and annotated 91 molecular markers with potential utility for prostate cancer, including PSA and KLK2 (20).
In the paper being published in The Journal of Biological Chemistry, Compugen's scientists report the identification of unusual mRNA splice variants of the KLK2 and KLK3 genes.
To address this issue, we measured the mRNA copy number in 2 AR-regulated prostate-specific genes [KLK3 (kallikrein-related peptidase 3) and KLK2 (kallikrein-related peptidase2)] (11) in blood prepared with the PAXgene Blood RNA System (PreAnalytiX).
For example, at the mRNA level, KLK2, 3, 4, 11, and 15 are highly expressed in prostate tissue (2).