The highest concentrations of KLK12 were found in bone marrow and bone, followed by adult and fetal colon and stomach.
High levels of KLK12 were found in CVF, with moderate concentrations in breast milk, breast cancer cytosol, saliva, and urine.
The KLK12 protein expression pattern has not been characterized; however, 1 study reported KLK12 expression in microvascular endothelial cells (35).
KLK12 is a novel serine protease and a new member of the human kallikrein gene family-differential expression in breast cancer.
In addition, KLK12 was found to be up-regulated by androgens and progestins in prostate cancer cell lines and by estrogens and progestins in breast cancer cell lines (28).
(a) Official Name when first First GenBank First kallikrein cloned submission publication name KLK4 Prostase AF113141 (24) KLK5 KLK-L2 AF135028 (23) KLK6 Neurosin D78203 (mRNA) (73) AF149289 (Full gene) (22) KLK7 HSCCE (b) L33404 (mRNA) (74) AF166330 (Full gene) (13) KLKS Neuropsin AB009849 (75) KLK9 KLK-L3 AF135026 (76) KLK10 NES1 NM 002776 (mRNA) (58) AF055481 (Full gene) (77) KLK11 TLSP ABO12917 (mRNA) (78) AF164623 (Full gene) (79) KLK12 KLK-L5 AF135025 (28) KLK13 KLK-L4 AF135024 (14) KLK14 KLK-L6 AF161221 (27) KLK15 KLK15 AF242195 (7) (a) A brief history describing the discovery of the three classic kallikreins has been published in a recent review (54).
New gene Previous gene New protein symbol (a,b) symbol(s) symbol KLK1 KLK1 hK1 KLK3 KLK3 hK3 KLK2 KLK2 hK2 KLK4 PRSS17, KLK-L1, KLK4 hK4 KLK5 KLK-L2 hK5 KLK6 PRSS9 hK6 KLK7 PRSS6 hK7 KLKS PRSS19 hK8 KLK9 KLK-L3 hK9 KLK10 PRSSL1, hK10 KLK11 PRSS20 hK11 KLK12
KLK-L5 hK12 KLK13 KLK-L4 hK13 KLK14 KLK-L6 hK14 New gene symbol (a,b) Other protein names/symbols KLK1 Pancreatic/renal kallikrein, hPRK KLK3 Prostate-specific antigen, PSA KLK2 Human glandular kallikrein 1, hGK-1 KLK4 Prostase, KLK-L1 protein, EMSP1 KLK5 KLK-L2 protein, HSCTE KLK6 Zyme, protease M, neurosin KLK7 HSCCE KLKS Neuropsin, ovasin, TADG-14 KLK9 KLK-L3 protein KLK10 NES1 protein KLK11 TLSP/hippostasin KLK12
KLK-L5 protein KLK13 KLK-L4 protein KLK14 KLK-L6 protein New gene GenBank symbol (a,b) Accession No.