KLK10

KLK10

A gene on chromosome 19q13 that encodes a serine protease which is expressed in the breast, ovary and prostate; it has a tumour suppressor role in breast and prostate cancer.
References in periodicals archive ?
We determined that the UMSCC1 and OSC19 Pre375 cells had reductions in the mRNA expression levels of KLK10, by 99% and 81%, respectively (Figure 8, B).
edu/exomeChip/Proposed Content/codingContent) have indicated the occurrence of stop codons in several KLK genes, including KLK4, KLK9, KLK10, and KLK14.
3B)] (17), D1O1 (deiodinase, iodothyronine, type I) (16), DMN1 (33), VHL (von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase) (35), H1F1A [hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)] (35), KLK10 (kallikrein-related peptidase 10) (31), and KLK1 (kallikrein 1) (36).
6] Nonstandard abbreviations: NAF, nipple aspirate fluid; MS/MS, tandem mass spectrometry; LC, liquid chromatography; KLK10, kallikrein 10.
KLK10 was found at high concentrations in the tonsil and skin (adult and fetal).
Steroid hormone regulation of the human kallikrein 10 (KLK10) gene in cancer cell lines and functional characterization of the KLK10 gene promoter.
Previously, several other kallikreins, including KLK4, KLK5, KLK6, KLK7, KLK8, KLK9, KLK10, KLK11, KLK14, and KLK15, have been associated with various forms of malignancy and especially cancers of the ovary, breast, prostate, and testis [reviewed in Refs.
KLK6 (zyme/protease M) was isolated by differential display from an ovarian cancer library (57), and KLK10 (NES1) was cloned by subtractive hybridization from a breast cancer library (58) and later shown to act as a tumor suppressor gene (59).
On the basis of the amino acid sequences, the closest relatives of KLK4 within the human kallikrein gene family are those that encode PSA (38% identity), the human stratum corneum chymotryptic enzyme (45% identity), and KLK6 (zyme/ neurosin/protease M; 38% identity) (6); the last and KLK10 are implicated in ovarian cancer (7, 8).
KLK10 (also known as the normal epithelial cell-specific 1 gene; NES1) appears to be a novel tumor suppressor that is down-regulated during breast cancer progression (15).