Further, the Company believes that study results support the determination of a dose range to normalize KLK1
levels in CKD patients for its upcoming Phase II study work.
The study also demonstrated a dose range which the company believes will restore normal KLK1
levels in CKD patients.
Our published study showed that IL-17 activates the kallikrein-kinin system (KKS) through the induction of renal expression of kallikrein 1 (Klk1
) during systemic fungal infection .
Previous animal studies have suggested that altered expression of the KLK1
gene, which results in the transcription/translation of the serine protease kallikrein, may be related to AKI.
A list of environmental indicators Environmental indicators Category Name Notation Natural Fossil energy use during transportation KEF1 resource use Fossil energy use during loading-unloading KEF2 Rate of using renewable resources KEF3 Energy Energy efficiency of transportation KE1 efficiency Technology Level of technology involved during vehicle KT1 construction Emissions Total C[O.sub.2] emissions KLK1
to air Total N[O.sub.x] emissions KLK2 Total PM emissions KLK3 Total S[O.sub.2] emissions KLK4 Emissions to Emissions to soil and water KFV1 soil and water Waste generation KFV2 Table 3.
The team also exposed nerve cells isolated from mice to KLK1
or KLK6 in the laboratory, and found the enzymes promoted nerve-cell loss.
All of KLK3 was deleted in individual S8, along with KLK15 and KLK1
(upstream of KLK3), and KLK2 (downstream of KLK3) (see Appendix 5 in the online Data Supplement).
The validated target genes for miR-224 are AP15 (apoptosis inhibitor 5) (21), AP2M1 (adaptor-related protein complex 2, mu 1 subunit) (33), CDC42 [cell division cycle 42 (GTP binding protein, 25 kDa)], CXCR4 [chemokine (C-X-C motif) receptor 4] (30), SMAD4 (SMAD family member 4) (34), SMAD5 (SMAD family member 5) (17), SLMAP (sarcolemma-associated protein) (17), H3.3B [H3 histone, family 3B (H3.3B)] (17), D1O1 (deiodinase, iodothyronine, type I) (16), DMN1 (33), VHL (von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase) (35), H1F1A [hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)] (35), KLK10 (kallikrein-related peptidase 10) (31), and KLK1
(kallikrein 1) (36).