KLF6

KLF6

A gene on chromosome 10p15 that encodes a zinc finger protein belonging to the Kruppel-like family of transcription factors; it activates transcription, acting as a tumour suppressor.

Molecular pathology
Some KLF6 transcription variants have been linked to carcinogenesis.
References in periodicals archive ?
39) Two genes, KLF6 and NFKBIZ, were identified as part of a 6-gene panel used to predict the survival of patients with localized pancreatic ductal adenocarcinoma; both of these genes showed higher expression in the poor prognosis group.
For some transcription factors such as STAT1, AR, HLF, ZEB1, TCF21, ISL1, KLF6, HOXB13, SIM2 and FOXA1, the number of interactions in the metastasis stage decreased dramatically (Table 3); the interaction numbers of other transcription factors, such as ZNF-529, FOXC1, MNX1, and JUNB, increased considerably in the metastasis stage, indicating network rewiring (Table 3).
As shown in table 3, for example, more than 2-fold decrease in the number of interactions for KLF6 was observed which controlled cell cycle progression and apoptosis.
However, it has also been shown that an oncogenic splice variant (KLF6-SV1) of KLF6 tumour suppressor gene targets BH3-only protein Noxa for degradation and blocks apoptosis effectively.
KLF6 induces apoptosis in prostate cancer cells through up-regulation of ATF3.
KLF6 and TP53 mutations are a rare event in prostate cancer: distinguishing between Taq polymerase artifacts and true mutations.
Basically we're able to make FOXO1 turn on KLF6, which tells cancer cells to die," senior author Goutham Narla said in a telephone interview.
The anti-psychotic drug could also be potentially used to combat other kinds of tumors, since the FOXO1 and KLF6 defects found in lung cancer are also seen in some breast and prostate cancers.
Eight of these 12 highly associated SNPs were within or proximate to known genes {ADDS [adducin 3 (gamma)1, CD47 (CD47 molecule), RPS6KA2 (ribosomal protein S6 kinase, 90kDa, polypeptide 2), KLF6 (Kruppel-like factor 6), PARK2 [parkinson protein 2, E3 ubiquitin protein ligase (parkin)), MSRA (methionine sulfoxide reductase A), NRSNI (neurensin 1), and NRXNI (neurexin 1)} that likely interact through three networks (Figure 1) predicted by multiple binary protein--protein interactions as statistically associated in the curated published literature (Brennan a al.
Sp1 ve KLF6 genleri kornea olusumunda rol oynamaktadirlar ve keratokonus olusumunda rol oynayabilirler.
He and his team are also responsible for the discovery of a novel tumor suppressor gene, KLF6 that is inactivated in a number of human cancers, including primary liver cancer.
Genetic and epigenetic alterations of the KLF6 gene in hepatocellular carcinoma.