KLF6

KLF6

A gene on chromosome 10p15 that encodes a zinc finger protein belonging to the Kruppel-like family of transcription factors; it activates transcription, acting as a tumour suppressor.

Molecular pathology
Some KLF6 transcription variants have been linked to carcinogenesis.
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References in periodicals archive ?
Many other SNPs of different genes involved in lipid metabolism, such as lipin 1 (LPIN1), oxidative stress, such as superoxide dismutase 2 (SOD2), and fibrogenesis, such as Kruppel-like factor 6 (KLF6), have been associated with the severity of liver damage in different studies on NAFLD patients [8-12].
Endochondral Actin Focal TGF[beta] MAPK ossification cytoskeleton adhesion signaling signaling FGF2 FGF1 ITGA6 UCHL5 STMN1 TGFB2 FGF2 STYK1 CDC2 DUSP1 PLAT FGF5 CAV1 SMURF2 TRAF2 CALM1 FGF22 CAV2 NEDD9 BDNF ADAMTS1 KRAS CAV3 STAMBPL1 MAP3K5 OPG NRAS LAMC2 CCNB2 ACVR1C C11orf13 THBS1 RBL1 KRAS F2R PXN MAPK8 TGFB2 CRK RHOB PARD6A NRAS PAK1 PDPK1 CAV1 PPP5C ARHGEF7 MYLK2 TFDP1 PAK1 VIL2 PAK1 KLF6 CRK PXN MAPK8 FST MAPK8 BCL2 SERPINE1 CCND3 THBS1 CRK NOG HRAS Table 3: Genes involved in adipogenesis-related pathways that are upregulated in CYD-treated hMSCs.
Several transcription factors have been found in MDM2 transcriptional regulation, which include SP1, p53, NF-[kappa]B, and KLF6 [15-19].
As a coregulator of NF-[kappa]B, KLF6 regulates the expression of downstream inflammatory cytokines, such as MCP-1 and IL-8 [27].
KLF6 is a protein belonging to the family of Kruppel factors or transcription KLFs type, this transcription factor is characterized by three DNA binding domains, called zinc fingers.
This appears to complement earlier reports that KLF6 plays a critical role in oligodendrocyte differentiation [42]and further substantiates the role of KFL7 in myelin preservation and remyelination after SCI.
Li, "MicroRNA-181a promotes gastric cancer by negatively regulating tumor suppressor KLF6," Tumor Biology, vol.
(39) Two genes, KLF6 and NFKBIZ, were identified as part of a 6-gene panel used to predict the survival of patients with localized pancreatic ductal adenocarcinoma; both of these genes showed higher expression in the poor prognosis group.
For some transcription factors such as STAT1, AR, HLF, ZEB1, TCF21, ISL1, KLF6, HOXB13, SIM2 and FOXA1, the number of interactions in the metastasis stage decreased dramatically (Table 3); the interaction numbers of other transcription factors, such as ZNF-529, FOXC1, MNX1, and JUNB, increased considerably in the metastasis stage, indicating network rewiring (Table 3).
Madam, Kruppel-like factor 6 (KLF6) is a zinc finger transcription factor that induces apoptosis in cancer cells leading to suppression of tumour growth.
KLF6 and TP53 mutations are a rare event in prostate cancer: distinguishing between Taq polymerase artifacts and true mutations.