KLF2

KLF2

A gene on chromosome 19p13.11 that encodes a member of the Kruppel-like family of broadly expressed zinc finger transcription factors, which regulates T-cell trafficking by promoting expression of the lipid-binding receptor S1P1 (S1PR1) and the selectin CD62L.
References in periodicals archive ?
The failure of these cells to exit the tissue is currently thought to be due to their low expression of the transcription factor KLF2 and of S1PR1 and to their high expression of the C-type lectin CD69; as a result of these conditions, the cells fail to respond to an "exit cue" provided by S1P (sphingosine-1-phosphate), which is released mainly from lymphatic ECs.
Previous studies demonstrated that other KLF members, including KLF2, KLF4, and KLF5, are required for self-renewal of ESC in vitro and are functionally redundant in vitro and in vivo as well (Jiang et al.
Varias mutaciones tienden a favorecer el linaje Th2 como son las que ocurren en SLP-76, en el factor de transcripcion KLF2, las Tec quinasas Itk y Rlk, la transferasa de histonas CBP y el factor de transcripcion Id3.
The presence of faults in the KLF2 and NOTCH2 genes indicated that patients generally required intensive treatment for their disease more quickly.
Taking a new approach, the scientists used reprogramming methods to express two different genes, NANOG and KLF2, which reset the cells.