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[USA], Feb 24 (ANI): According to a new study published in the online edition of JCI Insight, elevated blood sugar levels leads to muscle atrophy and two protein, WWP1 and KLF15, play key roles in this phenomenon.
They found that the abundance of transcription factor KLF15 increased in skeletal muscle of diabetic mice, and mice that lack KLF15 specifically in muscle were resistant to diabetes-induced skeletal muscle mass decline (Figure 1).
The immune-precipitated genomic DNA was subjected to qPCR for the promoter regions of PPARG, KLF15 (related to adipogenesis) and SP7, ALPL (related to osteogenesis).
KLF15 has been reported to synergistically interact with CEBP[alpha] to induce adipogenesis via increasing the activity of PPAR[gamma]2 and CEBP[alpha].
In fact, miR-133 was observed to target the Klf15 mRNA (Krueppel-like factor 15), inhibiting this transcriptional factor, which is an enhancer of Slc2a4 expression; thus miR-133 leads to the reduction in GLUT4 expression and in insulin-stimulated glucose uptake in rat cardiomyocytes .
Nishi et al., "MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control in cardiac myocytes," Biochemical and Biophysical Research Communications, vol.
Several nucleoproteins (MISP, KLF10, KLF15, PPP1R18, and RXR[beta]) have been identified by affinity chromatography and mass spectrometry and could respond to TPA stimulation and regulate LCN2 expression in esophageal cancer cells [19, 20].
(34.) Li J, Yang Y, Jiang B, Zhang X, Zou Y, Gong Y Sp1 and KLF15 regulate basal transcription of the human LRP5 gene.
Interestingly, KLF15 as a central regulator of stress response interacts with components of the Wnt pathway, resulting in inhibition of [beta]-catenin/Tcf-transcriptional activity in cardiac cells .
Jain's group discovered a protein called KLF15 that helps regulate the heart's electrical activity, and occurs in the body in levels that change like clockwork throughout the day.
Pollard discovered that a molecule called KLF15 (Kruppel-like transcription factor-15) controls the actions of estradiol and progesterone in the endometrium by inhibiting the production MCM2, a protein involved in DNA synthesis.
The answer begins with a controller of the circadian clock - kruppel-like factor 15 (Klf15), which has been a long-time target of the laboratory of Dr.
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