Other genes associated with MODY are infrequently detected: HNF1B, IPF, NEUROD, PDX1, KLF11
, CEL, PAX4, BLK, ABCC8 and KCNJ11 (3).
further demonstrated that KLF11, a novel PPAR[gamma] coregulator, interacted with PPAR[gamma] and suppressed miRNA-15a, leading to endothelial protection both in CEC cultures and cerebral microvasculature following ischemic stimuli .
Hamblin et al., "KLF11 mediates PPARgamma cerebrovascular protection in ischaemic stroke," Brain, vol.
Endochondral Actin Focal ossification cytoskeleton adhesion VEGFA FGF2 COL11A1 ADAMTS4 FGFR1 COL3A1 PLAT4 TMSB4X COL4A1 COL10A1 GNA13 COL4A2 TGFB2 PDGFA COL4A4 PTHrP FGF1 COL5A1 FGF2 ENAH COL5A2 C4ST1 MSN COL1A1 FGFR1 GSN LAMC2 PDGFRB PDGFRB THBS2 COL1 KRAS CAV2 MRAS ARHGAP5 SOS2 PTEN AKT3 PDGFA PDGFC PGF ITGA2 PDGFRB RAP1B MAPK8 TGF[beta] MAPK signaling signaling Adipogenesis SMURF1 MAPK8 FOXO1A MAPK8 NGFB TRIB3 SKP1 PDGFRB PCK2 NEDD9 RASA2 EGR2 ETS1 SOS2 DDIT3 KLF11
KRAS GADD45A ATF3 MRAS GADD45B FOSB NF1 HIF1A SKIL RAP1B IRS1 SMURF1 DUSP1 MEF2D ZFYVE16 DDIT3 FAS HSPB1 SPOCK IL1A FAS TGFB2 MAP313 ZAK AKT3 MAP3K8 GADD45A Table 2: Genes involved in osteogenesis-related pathways that are downregulated in CYD-treated hMSCs.
Progesteronun reseptorune baglanmasini engelleyerek, kendileri progesteron reseptorune baglanir ve buyume faktorlerini (IGF-1,EGF, TGF-b3,VEGF-A ve VEGF-B) azaltir, BCL2 ekspresyonunu azaltip ve KLF11
ve PLIN2 ekspresyonunu arttirarak ekstraseluler matriks formasyonunu ve proliferasyonunu azaltip, apoptozu arttirirlar.
When bound by the antiprogestin RU486 the progesterone receptor begins a series of events ending in the increase of Kruppel-like factor 11 (KLF11).
Reierstad et al., "Transcription factor KLF11 integrates progesterone receptor signaling and proliferation in uterine leiomyoma cells," Cancer Research, vol.
The expression of KLF11
(TIEG2), a monoamine oxidase B transcriptional activator in the prefrontal cortex of human alcohol dependence.
Siersbaek et al., "Browning of human adipocytes requires KLF11
and reprogramming of PPAR[gamma] superenhancers," Genes & Development, vol.
Epigenetic Regulation of Uterine Biology by Transcription Factor KLF11
via Post-translational Histone Deacetylation of Cytochrome p450 Metabolic Enzymes.
On the other hand, there are as many as 78 proteins, containing zinc finger, which can interact with LOXL2-WT-DEGs, such as ZNF19, ZNF292, KLF11
, CREB5, SNAI2, and SP2.
First, FXR activation induces the expression of glucose-dependent transcription factor krueppel-like factor 11 (KLF11
), which is an essential modulator for insulin gene transcription.