Functional analysis suggested that variation, in circadian genes including BMAL1, CRY2, CSNK1E, NPAS2, PER3, REV1, and downstream transcription factors KLF10
and SENP3 through disruption of hormonal pathways or changes in light/dark schedules, is associated with ovarian cancer.
There were significant differences across SLE, RA, and pSS, such as IL6R (P = 5.65E - 79), KLF10
(P = 2.69E - 75), NR1H3 (P = 6.05E - 73), CMTM4 (P = 1.69E - 68), CD164 (P = 3.37E - 59), TNFRSF21 (P =3.63E - 51), and STAT3 (P = 2.26E - 49).
Notable upregulated genes were involved in neuron differentiation ( BTG2, NTNG2, DLL1, HES1, NR4A2, STAT3, and VEGF-A ), myeloid cell and osteoclast differentiation ( KLF10
, TOB2, and ZFP36 ), cellular and macromolecular biosynthetic process ( KLF13, MKL1, HES1, MYOG, NR4A1, NR4A2, STAT3, and MAF ), and skeletal system development (JUND, KLF10
, NAB2, MYOG, and TIPARP ).
Wang et al., "Klf10
regulates odontoblast differentiation and mineralization via promoting expression of dentin matrix protein 1 and dentin sialophosphoprotein genes," Cell and Tissue Research, vol.
Several nucleoproteins (MISP, KLF10, KLF15, PPP1R18, and RXR[beta]) have been identified by affinity chromatography and mass spectrometry and could respond to TPA stimulation and regulate LCN2 expression in esophageal cancer cells [19, 20].
The full-length cDNAs for MISP, KLF10, KLF15, PPP1R18, and RXR[beta] were amplified by RT-PCR.
Stably transfected EC109 cell lines with high expression of MISP, KLF10, KLF15, PPP1R18, and RXR[beta] were transfected with 0.5 [micro]g pGLB152 and 0.01 [micro]g pRLTK.
The mRNA levels of MISP, KLF10, KLF15, PPP1R18, and RXR[beta] were determined by PCR amplification.
The serine, threonine, and tyrosine phosphorylation sites in MISP, KLF10, KLF15, PPP1R18, and RXR[beta] proteins were analyzed by NetPhos 2.0 Serve (http://www.cbs.dtu.dk/services/NetPhos/).
MISP, KLF10, KLF15, PPP1R18, and RXRfi Upregulate LCN2 Promoter Activity and mRNA Expression.
Effects of MEK Inhibitors on Transcriptional Activation by MISP, KLF10, KLF15, PPP1R18, and RXR/3.
Recently Foo et al., (2015) have discovered novel associations at 3q27.3 (ST6GAL1), 11p11.2 (ACCS) and 8q22.3 (KLF10