KLF1


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KLF1

A gene on chromosome 19p13.2 that encodes a haematopoietic-specific transcription factor that induces high-level expression of adult beta-haemoglobin and other erythroid genes.

Molecular pathology
Heterozygous loss-of-function mutations of KLF1 result in dominant In(Lu) blood phenotype.
References in periodicals archive ?
(2010) Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin.
(2010) KLF1 regulates BCL11A expression and [gamma]- to [beta]-globin gene switching.
Morsilli et al., "SCF-mediated [gamma]-globin gene expression in adult human erythroid cells is associated with KLF1, BCL11A and SOX6 down-regulation," Blood Cells, Molecules, and Diseases, vol.