KITLG

(redirected from KIT ligand)

KITLG

A gene on chromosome 12q22 that encodes KIT tyrosine kinase receptor ligand, which plays a key role in regulating cellular activities (such as: cell survival and proliferation; haematopoiesis; stem cell maintenance; gametogenesis; mast cell development; migration and function; and in melanogenesis) by activating multiple signalling pathways.

Molecular pathology
KITLG mutations cause familial progressive hyperpigmentation.
References in periodicals archive ?
This factor is also named mast cell growth factor or KIT ligand.
It then must bind a specific sequence of DNA located in a gene called the KIT ligand oncogene (KITLG), which stimulates melanocyte production, causing the skin to tan.
This elevation, or "activation," of p53 stimulated the production of a protein called Kit ligand that stimulates the growth of pigment cells, which turned the mice's skin darker than normal.
Expression of c-kit and kit ligand proteins in normal human tissues.