KITLG

(redirected from KIT ligand)

KITLG

A gene on chromosome 12q22 that encodes KIT tyrosine kinase receptor ligand, which plays a key role in regulating cellular activities (such as: cell survival and proliferation; haematopoiesis; stem cell maintenance; gametogenesis; mast cell development; migration and function; and in melanogenesis) by activating multiple signalling pathways.

Molecular pathology
KITLG mutations cause familial progressive hyperpigmentation.
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References in periodicals archive ?
This factor is also named mast cell growth factor or KIT ligand. Mast cells develop from CD34+ progenitor cells by way of stem cell factor (10, 11).
In this context, Glial cell line-Derived Neurotrophic Factor (GDNF), Fibroblast Growth Factor 2 (FGF2) and Kit Ligand (KITLG) are of the most important growth factors which have been identified to play pivotal role in regulation of SSCs development (2-4).
It then must bind a specific sequence of DNA located in a gene called the KIT ligand oncogene (KITLG), which stimulates melanocyte production, causing the skin to tan.
Leder, "The kit ligand: a cell surface molecule altered in steel mutant fibroblasts," Cell, vol.