KISS1R

KISS1R

A gene on chromosome 19p13.3 that encodes a Gq/G11 protein-coupled receptor that signals by stimulating phospholipase C, resulting in Ca2+ mobilisation. KISS1R is highly expressed in the pancreas, placenta and brain, and slightly expressed in the small intestine, kidney, lung, liver and heart. It plays a key role in the neuroendocrine control of the gonadotrophin axis and may inhibit metastases.
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References in periodicals archive ?
Determination of KISS1, KISS1R and Kisspeptin in fat tissue of normal weight and obese humans and correlations between Serum Kisspeptin and leptin.
Down-regulation of hypothalamic kisspeptin and its receptor, Kiss1r, mRNA expression is associated with stress-induced suppression of luteinizing hormone secretion in the female rat.
Normosmic idiopathic hypogonadotropic hypogonadism due to novel homozygous nonsense c.C969A (p.Y323X) mutation in the KISS1R gene in three unrelated families.
Global Markets Direct's, 'KiSS-1 Receptor (G-Protein Coupled Receptor 54 or G-Protein Coupled Receptor OT7T175 or hOT7T175 or Hypogonadotropin-1 or Kisspeptins Receptor or Metastin Receptor or KISS1R or GPR54) - Pipeline Review, H1 2016', provides in depth analysis on KiSS-1 Receptor (G-Protein Coupled Receptor 54 or G-Protein Coupled Receptor OT7T175 or hOT7T175 or Hypogonadotropin-1 or Kisspeptins Receptor or Metastin Receptor or KISS1R or GPR54) targeted pipeline therapeutics.
Previous research studies showed that mutations in KISS1R were associated with impaired pubertal maturation (Oakley et al., 2009).
Grundker, "Anti-proliferative effects of kisspeptin 10 depend on artificial GPR54 (KISS1R) expression levels," Oncology Reports, vol.
Depending on age and sex, five genes in the hypothalamus were affected by PCB treatment: Kiss1 (which stands for kisspeptin 1), Kiss1r (kisspeptin 1 receptor), Gper (G-protein-coupled estrogen receptor), Tac2 (neurokinin B) and Pdyn (prodynorphin).
Kisspeptin is the product of the KISS1 (1) (KiSS-1 metastasis suppressor) gene and is the ligand for the G-protein-coupled receptor, now known as the KISS1 receptor (KISS1R) [2] (1).
The coding and neighboring intronic regions of the known or strong candidate genes for nIHH (GNRHR, GNRH1, TACR3, TAC3, FGFR1, KISS1R, and KISS1) or KS (KAL1, FGFR1, PROK2, PROKR2) were amplified by polymerase chain reaction (PCR).
Its receptor, KISS1R, also known as GPR54, is encoded by a gene mapping on chromosome 19p13.3.
The consensus C-terminal decapeptide, common to all KPs, is the minimum amino acids sequence mandatory both for binding and activation of G protein-coupled receptor, GPR54 (recently named as KISS1R in human and kiss1r in other animals) (Kotani et al., 2001; Muir et al., 2001; Ohtaki et al., 2001; Gottsch et al., 2009).