KISS1R

(redirected from KISS1 receptor)

KISS1R

A gene on chromosome 19p13.3 that encodes a Gq/G11 protein-coupled receptor that signals by stimulating phospholipase C, resulting in Ca2+ mobilisation. KISS1R is highly expressed in the pancreas, placenta and brain, and slightly expressed in the small intestine, kidney, lung, liver and heart. It plays a key role in the neuroendocrine control of the gonadotrophin axis and may inhibit metastases.
References in periodicals archive ?
Kisspeptin is the product of the KISS1 (1) (KiSS-1 metastasis suppressor) gene and is the ligand for the G-protein-coupled receptor, now known as the KISS1 receptor (KISS1R) [2] (1).
1] Human genes: KISS1, KiSS-1 metastasis-suppressor; KISS1R, KISS1 receptor.
2] Nonstandard abbreviations: KISS1R, KISS1 receptor (previous symbol, GPR54); IR, immunoreactivity.