KISS1


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KISS1

A gene on chromosome 1q32 that encodes a G protein-coupled receptor which suppresses metastases of melanomas and breast carcinomas without affecting their tumourigenicity. KISS1 may inhibit chemotaxis and invasion, and attenuate metastasis in melanomas.
References in periodicals archive ?
Molecular cloning and characterization of KISS1 promoter and effect of KISS1 gene mutations on litter size in the goat.
Determination of KISS1, KISS1R and Kisspeptin in fat tissue of normal weight and obese humans and correlations between Serum Kisspeptin and leptin.
It plays a focal part in the control of the HPG axis neuronal activity (highly sensitive to the body energy stores and nutritional status) to trigger puberty as well as affects fertility.7,8 KP not only triggers onset of puberty but also relays information about body's energy stores to the central nervous system by modulating negative and positive feedback of gonadal steroids.9 The expression of KISS1 is thus influenced by nutritional status where KP neurons function as a gatekeeper of reproductive function at pivotal times in the human lifespan, down-regulating fertility at times of physical strain such as over-exercise or weight loss.10
Silveira-Neto et al., "Mutations of the KISS1 gene in disorders of puberty," The Journal of Clinical Endocrinology and Metabolism, vol.
Hence, exposure to DEHP did not alter the number of kisspeptin-immunoreactive neurons or fiber density expression, nor did it alter activity of the kiss1 promoter, shown using a GFP reporter in the two hypothalamic nuclei involved in the regulation of the gonadotropic axis.
In rodents, Kiss1 neurons prominently reside in the Arc and preoptic area [40, 41].
Likewise, the recently identified involvement of epigenetics in the control of Kiss1 expression at puberty, a crucial stage in sexual development that is metabolically gated, suggests also the contribution of these regulatory mechanisms to this phenomenon.
Developmental changes in hypothalamic Kiss1 expression during activation of the pulsatile release of luteinising hormone in maturing ewe lambs.
Kisspeptins (KP) are peptides that have the potential for therapeutic use [11] which are expressed by the tumor melanoma cell metastasis suppressor gene KiSS1 [12]and have a major role in reproduction and metabolic regulation [13-15].
Updated, this edition has homeostasis highlights beginning each chapter; more art, new figures, and more electron micrographs; new questions at the ends of sections; new content on the discovery of tunneling nanotubes, the default mode network, global workspace theory, the synaptic homeostasis hypothesis, and the influence of kisspeptin signals from kiss1 neurons in the control of gonadotropin releasing hormone secretion; more on innate immunity and brown fat; and online tutorials and animations and virtual physiology labs.