CDKN1C

(redirected from KIP2)

CDKN1C

A gene on chromosome 11p15.5 that encodes a strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation.

Molecular pathology
CDKN1C mutation is implicated in sporadic cancers and Beckwith-Wiedemann syndrome, suggesting a role in tumour suppression.
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References in periodicals archive ?
Simultaneous detection of imprinted gene expression (p57(KIP2)) and molecular cytogenetics (FICTION) in the evaluation of molar pregnancies.
KIP2 Yarn, 1012 Springwater Ave., Wenatchee; retail yarn and knitting supplies.
Cited2 knockdown reduced the expression of cell cycle inhibitor Cdkn1c/p57/ Kip2 in neonatal CMs [14].
The different expression profiles of the target genes p27(Kip1), p57(Kip2), and c-kit between the two cell types might be related to the opposite effects [85, 93].
Dirks et al., "Expression of p57(KIP2) potently blocks the growth of human astrocytomas and induces cell senescence," The American Journal of Pathology, vol.
Table 3: Comparison of HandE stains with p57 KIP2 IHC results in HM.
The usefulness of p57 KIP2 immunohistochemical staining and genotyp-ing test in the diagnosis of the hydatidiform mole.
Chemopreventive potential of an ethyl acetate fraction from Curcuma longa is associated with upregulation of p57(kip2) and Rad9 in the PC-3M prostate cancer cell line.
Feinberg, IGF2, H19, p57 KIP2, and LIT1 and the Beckwith-Wiedemann Syndrome, in INBORN ERRORS OF DEVELOPMENT: THE MOLECULAR BASIS OF CLINICAL DISORDERS OF MORPHOGENESIS 758, 758-65 (Charles J.
The contrasting role of p57(KIP2) and p21(Waf1/CIP1/SDI1) in transplanted human and bovine adreno-cortical cells have also been reported.
Cdk inhibitors (CKIs), such as p21 (Cip1) p27 (Kip1) and p57(Kip2), play a critical role in the negative control of cyclin/Cdk complexes and cell growth (Yue and Jiang, 2005).