CDKN1B

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CDKN1B

A gene on chromosome 12p13.1-p12 that encodes a cyclin-dependent kinase inhibitor, which binds to and prevents activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, thus controlling cell cycle progression at G1. Degradation of cyclin-dependent kinase inhibitor 1B is triggered by its CDK-dependent phosphorylation and subsequent ubiquitination by SCF complexes, and is a necessary step for cell transition from quiescence to the proliferative state.
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The role of p21(waf1/cip1) and p27(Kip1) in HDACi-mediated tumor cell death and cell cycle arrest in the E[micro]-myc model of B-cell lymphoma.
Campbell et al., "p27(Kip1) is required to maintain proliferative quiescence in the adult cochlea and pituitary," Cell Cycle, vol.
Lee, "Constitutively active FOXO4 inhibits Akt activity, regulates p27 Kip1 stability, and suppresses HER2-mediated tumorigenicity," Oncogene, vol.
High level expression of p27(kip1) and cyclin D1 in some human breast cancer cells: inverse correlation between the expression of p27(kip1) and degree of malignancy in human breast and colorectal cancers.
Moreover, AMPK activation in immature oocytes apparently downregulates two MPF stimulators--target of rapamycin (TOR) and nitric oxide synthase (NOS) (Stricker, 2011, 2012)--while upregulating the MPF inhibitor p27 Kip1 (Stricker, 2011), collectively indicating that AMPK signaling serves to inhibit GVBD in nemerteans (Stricker et al., 2010a, b; Stricker, 2011).
p27 (Kip1) controls cytokinesis via the regulation of citron kinase activation.
Saint-Laurent et al., "sst2 somatostatin receptor mediates cell cycle arrest and induction of p27(Kip1).
Liao, "3-hydroxy-3- methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing Rho GTPase-induced down-regulation of p27(Kip1)," The Journal of Biological Chemistry, vol.
Kip1) cell cycle 2006 progression 8 CDK6 Probably involved in Chilosi et al.
Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antioestrogen resistance in human breast cancer cells.
Regulation of the p27 (Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation.