KIF7

KIF7

A gene on chromosome 15q26.1 that encodes a kinesin-like protein regulator of Sonic hedgehog (Shh) pathway, acting downstream of SMO. KIF7 downregulates Shh by preventing inappropriate activation of the transcriptional activator GLI2 in
absence of ligand; it upregulates the pathway by preventing the processing of the transcription factor GLI3 into its repressor form. KIF7 is required for efficient localisation of GLI3 to cilia in response to Shh. It may also act as a ciliary motor.
References in periodicals archive ?
These genes can be listed as follows: AHI1, ARL13B, C5ORF42, CC2D2A, CEP41, CEP290, INPP5E, KIF7, MKS1, NPHP1, OFD1, RPGRIP1L, TCTN1, TCTN2, TCTN3, TMEM67, TMEM138, TMEM216, and TMEM23 [3].
In the absence of Hh ligand, Gli3 is restricted to a microtubule complex composed of Kif7 (kinesin family member 7), SuFu (suppressor of fused), CK1 (casein kinase 1), PKA (protein kinase A), and Gsk3[beta] (glycogen synthase kinase 3 beta) and is phosphorylated by PKA, GSK3[beta], and CK1.