KIF5B

KIF5B

A gene on chromosome 10p11.22 that encodes a microtubule-dependent motor protein required for normal distribution of mitochondria and lysosomes.
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RET fusion variants KIF5B (K15:R12, K16:R12, K22:R12, K23:R12, K24:R11, K24:R8); CCDC6 (C1:R12); TRIM33 (T14:R12): Patients with mutations in this oncogene may benefit from treatment with cabozantinib or vandetinib.
Abbreviations: EML4, echinoderm microtubule-associated protein-like 4; KIF5B, kinesin family member 5B; KLC1, kinesin light chain 1; TFG, tropomyosin receptor kinase-fused gene.
Recent research has also revealed that RET and KIF5B gene fusion (gene mutation) occurs in some lung cancer patients, which means that RET tyrosine kinase inhibitors may potentially be used in the treatment of lung cancer patients with this gene mutation.
Whole-transcriptome sequencing studies performed by Kohno et al reported a novel fusion between KIF5B (the kinesin family 5B gene) and the ret proto-oncogene (RET), leading to an activation of RET kinase in lung adenocarcinomas.
In NSCLC, there are multiple variants of the EML4-ALK fusion, and ALK may sometimes have other fusion partners such as TFG and KIF5B.
59) At least 9 EML4-ALK fusion variants have been reported, and ALK variants can also have 5 other partners, such as KIF5B and TGF, with all variants containing the kinase domain of ALK.