KIF4A

KIF4A

A gene on chromosome Xq13.1 that encodes an ATP-dependent, microtubule-based motor protein involved in the intracellular transport of membranous organelles. KIF4A translocates the protein regulator of cytokinesis 1 (PRC1) to the plus ends of interdigitating spindle microtubules during the metaphase-to-anaphase transition, which is an essential step in forming an organised central spindle midzone and midbody and in successful cytokinesis. KIF4A may play a role in mitotic chromosomal positioning and bipolar spindle stabilisation.
References in periodicals archive ?
The most significant 10 DEGs were HOXB7 (FDR=1.69E-07), SMYD3 (FDR=2.36E-07), ECT2 (FDR=3.19E-07), CBX3 (FDR=4.69E-07), AURKA (FDR= 7.46E-07), WDHD1 (FDR=9.01E-07), MTHFD2 (FDR=2.87E-06), KIF4A (FDR=5.72E-06), DUSP12 (FDR=5.94E-06), and FNDC3B (FDR=6.18E-06).
Of note, the interaction of KIF4A and TOP2A provided the highest weight value of 0.999834.
Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A.J.
Other genes including BIRC5, an inhibitor of apoptosis; KIF4A, an ATP (adenosine triphosphate) dependent microtubule-based motor protein; and SEPT9, a member of the septin family involved in cytokinesis and cell cycle control, were upregulated and associated with poor prognosis.