KIF4A

(redirected from KIF4)

KIF4A

A gene on chromosome Xq13.1 that encodes an ATP-dependent, microtubule-based motor protein involved in the intracellular transport of membranous organelles. KIF4A translocates the protein regulator of cytokinesis 1 (PRC1) to the plus ends of interdigitating spindle microtubules during the metaphase-to-anaphase transition, which is an essential step in forming an organised central spindle midzone and midbody and in successful cytokinesis. KIF4A may play a role in mitotic chromosomal positioning and bipolar spindle stabilisation.
References in periodicals archive ?
Hirokawa, "KIF4 motor regulates activity-dependent neuronal survival by suppressing PARP-1 enzymatic activity," Cell, vol.
Other groups of potential playmakers in regenerative therapy, induced pluripotent stem cells (iPSC), have come to the scene by Takahashi and Yamanaka who successfully produced induced pluripotent stem cells (iPSC) using mouse embryonic and adult fibroblast cells and introducing four transcription factors SOX2, OCT 3/4, KIF4, and c-myc to cells [65].