KIF3B

KIF3B

A gene on chromosome 20q11.21 that encodes a protein that forms a heterodimer with kinesin family member 3A, tethering chromosomes to the spindle pole and aiding chromosome movement during mitosis and meiosis. KIF3B is a plus-end-directed microtubule motor protein that interacts with the SMC3 subunit of the cohesin complex; it may be involved in the intracellular movement of membrane-bound organelles.
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miRNAs Target Gene description PSMB5 Proteasome (prosome, macropain) subunit, beta type 5 KIF3B Kinesin family member 3B hsa-miR-127-3p ITGA6 Integrin, alpha 6 BCAS3 Breast carcinoma-amplified sequence 3 MTSS1L Metastasis suppressor 1-like SP3 Sp3 transcription factor MYCBP2 MYC-binding protein 2, E3 ubiquitin protein ligase hsa-miR-493-5p TCF7L2 Transcription factor 7-like 2 (T-cell specific, HMG box) UBE2V2 Ubiquitin-conjugating enzyme E2 variant 2 HIPK1 Homeodomain-interacting protein kinase 1 RAB10 RAB10, member RAS oncogene family UBE2D2 Ubiquitin-conjugating enzyme E2D 2 hsa-miR-409-3p KANSL1 KAT8 regulatory NSL complex subunit 1 MTF2 Metal response element binding transcription factor 2 ELF2 E74-like factor 2 (ETS domain transcription factor)
The transport of ciliary proteins from the cytoplasm to the ciliary tip, known as anterograde transport, depends on the heterotrimeric kinesin-2 protein, which consists of two motor subunits, KIF3A and KIF3B, and an accessory subunit, the kinesin-associated protein (KAP) [18].
Activation of PKC-[xi] and PKC-[lambda] stimulates Ras-related protein (RAB4A) activity, the association of RAB4A with kinesinlike protein KIF3B, and the interaction of KIF3B with microtubules.