KIF2A

KIF2A

A gene on chromosome 5q12-q13 that encodes a microtubule-associated motor protein required for normal brain development, which may regulate microtubule dynamics during axonal growth. KIF2A is required for normal progression through mitosis for normal congress of chromosomes at the metaphase plate, and is also required for normal spindle dynamics during mitosis. KIF2A promotes spindle turnover and is implicated in formation of bipolar mitotic spindles. It has microtubule depolymerisation activity.
References in periodicals archive ?
It has also been shown that importin [alpha] is involved in regulating spindle scaling during Xenopus development, by inhibiting the microtubule-destabilizing activity of the kinesin-13, kif2a. (102) Although the microtubule-destabilizing activity of kif2a was inhibited by soluble importin [alpha] during early phases of development, kif2a becomes more active later in development (stage 8), when importin [alpha] is more sequestered to the plasma membrane.
(2013) Mitotic spindle scaling during Xenopus development by kif2a and importin [alpha].
Broix et al., "Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly," Nature Genetics, vol.