Some of the important genes related to immune response and proliferation genes, such as cytochrome P450 1A1 (CYP1A1), histone H2B type 1 (HIST1H2BC), kinesin family member 20A (KIF20A), immunoglobulin G heavy chain (IgH), myomesin-2-like (MYOM2), and stathmin 1 (STMN1), were upregulated.
Increased gene expression was observed in KIF20A (FC: 2.11), CYP1A1 (FC: 2.01), IgH (FC: 8.43), HIST1H2BC (FC: 2.10), and STMN1 (FC: 2.23).
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In contrast, miR-200a-3p upregulation suppresses gene inhibitors for EED and EZH2 (KIF20A
and HSD17B11 for EED and CDK6 for EZH2) and allows these two transcription factors to positively affect the transcription of interferons IFNA1 and IFNA2.
In the first case study we end up with the marker genes for (i) the proliferation activity composed of 12 genes, CDC20, TK1, KNL1, CENPE, STIL, ANLN, NDC1, NUF2, KIF20A
, PLK4, CCNB1, and CCNA2, and (ii) the quiescence state composed of 12 genes: COL5A1, TGFBI, TCEA2, WNT9A, MMP11, LAMB1, KRT14, LTBP1, PHLDB1, TIMP3, LRP1, and COL18A1.