KIF11

KIF11

A gene on chromosome 10q24.1 that encodes a motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrests cells in mitosis.
Mentioned in ?
References in periodicals archive ?
Furthermore, SCEC tissues were found to possess interactive gene networks with FOXM1, TMPO, KIF11, NEK2, and CENPF as common skeleton centered on NUF2 (Supplementary information Figure S4).
It was found that expression of TP53 (HR 1.9, p = 31 x [10.sup.-7]) was associated with worse overall survival (OS) for glioma patients, as well as TOP2A (HR 4.4, p = 0), CDK1 (HR 4.8, p = 0), CCNB1 (HR 5.9, p = 0), CDC20 (HR 5.2, p = 0), CCNA2 (HR 5.1, p = 0), NDC80 (HR 5.8, p = 0), AURKA (HR 5.3, p = 0), BIRC5 (HR 5, p = 0), CCNB2 (HR 5.4, p = 0), KIF11 (HR 2.3, p = 15 x [10.sup.-10]), and MAD2L1 (HR 4.4, p = 0), while expression of PHLPP2 (HR 0.41, p = 1.3x [10.sup.-11]), DLG4 (HR 0.59, p = 35 x [10.sup.-5]), and MYC (HR 0.58, p = 2.1 x [10.sup.-5]) was associated with better overall survival (OS) for glioma patients (Figure 3).
We selected TP53, TOP2A, CDK1, CCNB1, CDC20, CCNA2, NDC80, AURKA, BIRC5, CCNB2, KIF11, and MAD2L1, which with worse overall survival situation according to the Kaplan-Meier plotter.
Two other genes, ZNF408 encoding zinc finger protein 408 and KIF11 encoding kinesin family member 11, are linked to FEVR, although the evidence of their association needs to be clarified.
Mission[R] esiRNA against mouse KIF11, FLUC, and mouse GSR, L-methionine, and BCNU were obtained from Sigma Aldrich.
The expression change of the 15 genes that were most up-regulated by E2 ranged from 16-fold for beta-casein (Csn2) to 4-fold for kinesin family member 11 (Kif11) (Figure 4B).
Although 8-PN weakly induced the expression of some of the E2 target genes (Kif11, Kif2c, Kif18a, Csn2), a significant counteracting effect of 3-MC on 8-PN-induced gene expression was observed for Csn2, Kif18a, and Kif11, in which the relative expression of the mRNA was significantly abrogated after co-treatment.
Microcephaly-lymphoedema-chorioretinal dysplasia KIF11. (8)
Mutations in KIF11 Cause Autosomal-Dominant Microcephaly Variably Associated with Congenital Lymphedema and Chorioretinopathy.
5 August 2014 - US personalised medicine specialist Caris Life Sciences unveiled Tuesday data from a case study showing that its Caris Molecular Intelligence tumour profiling service helped guide successful therapy with both a kinesin 11 (KIF11) inhibitor and imatinib for a patient with neuroendocrine carcinoma with an activating KIT mutation.
Nishioka et al., "Overexpression of KIF11 in gastric cancer with intestinal mucin phenotype," Pathobiology, vol.
For instance, a decrease of ced-3 expression by overexpression of the mammalian KIF11 homolog bmk-1 extends the lifespan of wild-type C.