KIF11

KIF11

A gene on chromosome 10q24.1 that encodes a motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrests cells in mitosis.
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For instance, a decrease of ced-3 expression by overexpression of the mammalian KIF11 homolog bmk-1 extends the lifespan of wild-type C.
The study, featured in the Journal of the National Comprehensive Cancer Network (JNCCN), demonstrated the first documented case of an activating KIT mutation in a neuroendocrine tumour (NET) and of successful therapy with both a KIF11 inhibitor and imatinib.