KRAS

(redirected from KI-RAS)

KRAS

A Kirsten ras oncogene homolog from the mammalian ras gene family on chromosome 12p12.1, which encodes a small GTPase in which a single amino acid substitution results in a transforming protein.

Molecular pathology
The KRAS transforming protein has been linked to various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas, colorectal carcinoma, acute myelogenous leukaemia, juvenile myelomonocytic leukaemia, gastric cancer, pilocytic astrocytoma, Noonan syndrome type 3, and cardiofaciocutaneous syndrome
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References in periodicals archive ?
Smith et al., "Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene," Nature, vol.
Sequence analysis revealed a constitutive mutation at codon 620 of the TSHR gene and a G12C Ki-RAS mutation.
Associations between dietary intake and Ki-ras mutations in colon tumors: a population-based study.
Ki-ras protooncogene mutations in sporadic colorectal adenomas: relationship to histologic and clinical characteristics.
Antiproliferative activity of a triplex-forming oligonucleotide recognizing a Ki-ras polypurine/polypyrimidine motif correlates with protein binding.
(13) In an autonomously functioning thyroid follicular carcinoma, a combination of mutations of TSH receptor and Ki-RAS was found to be responsible for hyperfunction of the tumor and the carcinogenic process.
Ki-ras gene mutations are invariably present in low-grade mucinous tumors of the vermiform appendix.
Mutations of Ki-ras oncogene codon 12 in betel quid chewing-related human oral squamous cell carcinoma in Taiwan Journal of oral pathology
Subject headings and keywords used in the search process were as follows: (1) K-ras, kirsten-ras, and ki-ras; (2) PC, pancreatic neoplasms, pancreatic cancer, adenocarcinomas of the pancreas, and pancreatic adenocarcinomas.
Type and number of Ki-ras point mutations relate to stage of human colorectal cancer.
Hahn, "Mutations of Ki-ras oncogene codon 12 in betel quid chewing-related human oral squamous cell carcinoma in Taiwan," Journal of Oral Pathology and Medicine, vol.