KDR


Also found in: Acronyms.

KDR

A gene on chromosome 4q11-q12 that encodes a vascular endothelial growth factor receptor known as kinase insert domain receptor, which is a type-III receptor tyrosine kinase. KDR is the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting.

Molecular pathology
KDR mutations have been linked to infantile capillary haemangiomas.
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KDR was founded in 1987 with the strong belief that satisfying the human element is the key factor in a successful relocation.
In the few M-form populations where it has been found, sequencing analysis of the upstream intron-1 of the kdr locus showed that the 1014F allele apparently occurred through introgression with the S-form (49).
KDR offers a varied fleet from the E K Kanoo and Motorcity agents; from two-door sports cars to family sedans and even commercial vehicles such as pick-ups, trucks and vans.
Binding of VEGF to the KDR leads to KDR dimerization, activation and autophosphorylation of the intracytoplasmic domains in specific tyrosine residues.
The takeover, along with the recent purchase of consumables distributor KDR, allows Life Technologies to serve South Korean clients through one channel, said Mark Smedley, president of Life Technologies for the Asia Pacific Japan region.
A critical discovery in this research was finding that the novel progenitor has a receptor protein on its cell surface called KDR, or vascular endothelial growth factor receptor 2, which until now, was thought to be restricted to endothelial cells that form vessels, the progenitors for endothelial cells and the progenitors blood cells.
Commenting on the partnership, Vishesh Bhatia, CEO, Jumbo Electronics said, "We, as Jumbo group, welcome our partner Lenovo and are very excited to represent Lenovo Smartphones in the capacity of KDR (Key Domestic Retail) Distribution Partner.
Death of microvascular cells due to the toxic irritating cellular condition may be responsible for up regulation of VEGF and it's receptor KDR to increase circulation to the affected areas in an attempt to remove those irritating molecules.
It was demonstrated that KDR can speed the matching of high-dimensional vectors by up to several orders of magnitude, compared to a linear search.
To date, however, these cases of multiple-insecticide resistance have been restricted by the relatively low prevalence of organophosphate/carbamate resistance and the limited effect that kdr mutations alone have on pyrethroid-based interventions (6).