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Histone demethylase KDM6B controlled HOX expression by removing histone 3K27 trimethylation (H3K27me3) and reduced KDM6B significantly by reducing osteogenic differentiation and increasing adipogenic differentiation .
Yu et al., "Histone demethylases KDM4B and KDM6B promotes osteogenic differentiation of human MSCs," Cell Stem Cell, vol.
In a recent study, it was also shown to inhibit ST2 cell differentiation toward the osteogenic linage by directly targeting lysine-specific demethylase 6b (Kdm6b), a regulator of osteoblast differentiation .
In search for epigenomic modifiers that control adipose tissue function and also impact on T2D pathogenesis, we have recently identified the transcriptional coregulators GPS2 (G-Protein Pathway Suppressor 2) and KDM6B (Histone Lysine Demethylase 6B, also called JMJD3) as strong candidates.Our hypothesis is that the clinically documented dysregulation of GPS2 (down) and KDM6B (up) expression and function during obesity leads to the closely linked epigenetic and transcriptional reprogramming of adipocytes and adipose tissue-macrophages, thereby enhancing the susceptibility to metabolic and inflammatory disturbances and the progression towards T2D.
Combining our results with the earlier publications, we propose lysine demethylase 6B (KDM6B) and vertnin (VRTN) as two interesting candidate genes for the loci on SSC12 and SSC7.
Epigenetic reprogramming of host epithelial cells through increased expression of KDM6A and KDM6B (jumonji domain containing 3) histone demethylase by HPV E7 oncogene has also been reported, and this was associated with dramatic reduction in trimethylation of H3K27.
The assay uses the company's biomarker development platform to provide concurrent in-vitro identification of antibodies against domains of Scl-70 (topoisomerase I), CENP-B, KDM6B and BICD2, within human serum or plasma.
Wang and his group identified a protein encoded by the gene Jmjd3 (also called KDM6B) as a roadblock in the stem cell conversion process.
Epigenetic Disease marks Alteration Reference Neural tube Histone (i) Myelomeningocele  defects (a) High levels of H3K4me2, H3K4me3, H3K27me2, and H3K27me3; (b) Low levels of KDM6B; (c) Decreased levels of H3K9ac, H3K18ac, and Gcn5.
He and his team found that KDM4B and KDM6B, two gene-activating enzymes, can promote stem cells' differentiation into bone cells by removing methyl markers from histone proteins.
Jia et al., "Demethylation of IGFBP5 by histone demethylase KDM6B promotes mesenchymal stem cell-mediated periodontal tissue regeneration by enhancing osteogenic differentiation and anti-inflammation potentials," Stem Cells, vol.
Zhang, "Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway," Cell Research, vol.
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