KDM5B

KDM5B

A gene on chromosome 1q32.1 that encodes lysine-specific demethylase 5B, which interacts with FOXG1 and PAX9 as a transcriptional co-repressor. Lysine K-specific methylase may act as a tumour suppressor for melanoma.

Molecular pathology
KDM5B favours breast cancer cell proliferation by repressing tumour suppressor genes BRCA1 and HOXA5.
References in periodicals archive ?
To test this hypothesis we will use biochemical, molecular biology and bioinformatics approaches to define the role of two crucial AR-KDM coregulators, KDM5B and KDM7A.
Individual Chromosomal coordinates Ref Var Gene 2 chr7:150753860-150753861 c T CDK5 5 chr10:84745342-84745343 c G NRG3 6 chr19:41081400-41081401 A G SPTBN4 12 chr14:21868326-21868327 C G CHD8 12 chr12:69653901-69653902 G A CPSF6 15 chr19:7624035-7624036 A G PNPLA6 15 chr19:38160418-38160419 C T ZNF781 17 chr3:448 72501-44872502 G A KIF15 17 chr2:63609084-63609085 G G WDPCP 18 chr5:179225540-179225541 T C MGAT4B 24R chr1:202 722 082-202 72 2083 G A KDM5B 24R chr12:123276605-123276610 GAGAA del CCDC62 26 chr1 7:62230319-62230320 G A TEX2 28 chr8:422 95080-422 95081 T C SLC20A2 29 chr3:122418851 -122418852 G A PARP14 30 chr3:125257391 -125257392 A G OSBPL11 30 chr7:94539852-94539853 G A PPP1R9A Individual A.A.
The histone methyltransferases (SET1, G9a, SUV39H1, and SUV39H2) and the histone demethylases (LSD1, KDM3A, KDM4A, KDM4B, KDM4C, KDM5A, KDM5B, KDM5C, and KDM5D) gene expression was detected by real-time quantitative PCR.
In order to investigate the cause of altered histone methylation patterns in LADA patients, we assessed mRNA levels of histone methyltransferases (SET1, G9a, SUV39H1, and SUV39H2) and the histone demethylases (LSD1, KDM3A, KDM4A, KDM4B, KDM4C, KDM5A, KDM5B, KDM5C, and KDM5D) in [CD4.sup.+] T lymphocytes by real-time quantitative PCR.
Histone 3 lysine 4 methylation was regulated by histone methyltransferase SET1 and histone demethylase LSD1, KDM5A, KDM5B, KDM5C, and KDM5D.
The mRNA level of histone methyltransferases gene (SET1, SUV39H1, SUV39H2, and G9a) and histone demethylases gene (LSD1, KDM3A, KDM4A, KDM4B, KDM4C, KDM5A, KDM5B, KDM5C, and KDM5D) was detected by real-time PCR.
(b) Relative mRNA levels of histone demethylases (LSD1, KDM3A, KDM4A, KDM4B, KDM4C, KDM5A, KDM5B, KDM5C, and KDM5D) in [CD4.sup.+] T lymphocytes from LADA patients (n = 26) and healthy controls (n = 26), the absolute of fold change > 2 was considered significant, LADA patients versus healthy controls; data are normalized against beta-actin.
Oktyabri et al., "KDM5B histone demethylase controls epithelial-mesenchymal transition of cancer cells by regulating the expression of the microRNA-200 family," Cell Cycle, vol.
Specifically, a 50 ppb developmental arsenic exposure increased global H3K4me3 (KE10) levels, decreased histone demethylase KDM5B, and increased the histone methyltransferase MLL expression in the DG and FC of male mice only (KE8) (Figure 1B).
KE8 Developmental arsenic exposure (50 ppb decreased histone demethylase KDM5B and increased expression of the histone methyltransferase MLL in the DG and FC of male mice only.
JARID1B, also known as lysine demethylase 5B (KDM5B), acts as an oncogene and contributes to hepatocarcinogenesis by promoting cell migration and invasion.
Although the mechanisms are not fully understood, arsenic also altered the expression of corresponding histone-modifying enzymes, including Mll and Kdm5b, in a sex-dependent manner (Tyler et al.